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Cnih4 cornichon family AMPA receptor auxiliary protein 4 [ Mus musculus (house mouse) ]

Gene ID: 98417, updated on 5-Mar-2024

Summary

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Official Symbol
Cnih4provided by MGI
Official Full Name
cornichon family AMPA receptor auxiliary protein 4provided by MGI
Primary source
MGI:MGI:1925828
See related
Ensembl:ENSMUSG00000062169 AllianceGenome:MGI:1925828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNIH-4; HSPC163; D530030D03Rik; E430023H19Rik
Summary
Predicted to enable CCR5 chemokine receptor binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Orthologous to human CNIH4 (cornichon family AMPA receptor auxiliary protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 8.3), placenta adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H4; 1 84.53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180977437..180996559)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181150366..181168994)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene degenerative spermatocyte homolog 1 pseudogene Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene nuclear VCP-like Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene WD repeat domain 26 Neighboring gene predicted gene, 50602 Neighboring gene predicted gene, 38664 Neighboring gene STARR-positive B cell enhancer ABC_E5875

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility. Dil S, et al. Dev Biol, 2023 Apr. PMID 36657507
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility.
    Title: Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein cornichon homolog 4
Names
cornichon homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030131.3 → NP_084407.1  protein cornichon homolog 4

    See identical proteins and their annotated locations for NP_084407.1

    Status: VALIDATED

    Source sequence(s)
    AC113084, AK021301, AW050376
    Consensus CDS
    CCDS15582.1
    UniProtKB/Swiss-Prot
    Q3TNM6, Q9CX13
    Related
    ENSMUSP00000115772.2, ENSMUST00000134115.8
    Conserved Domains (1) summary
    pfam03311
    Location:3 → 130
    Cornichon; Cornichon protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180977437..180996559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238890.4 → XP_011237192.1  protein cornichon homolog 4 isoform X1

    Conserved Domains (1) summary
    pfam03311
    Location:4 → 94
    Cornichon; Cornichon protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CX13.1 GenPept UniProtKB/Swiss-Prot:Q9CX13

Gene LinkOut

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