U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 98415, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nucks1provided by MGI
Official Full Name
nuclear casein kinase and cyclin-dependent kinase substrate 1provided by MGI
Primary source
MGI:MGI:1934811
See related
Ensembl:ENSMUSG00000026434 AllianceGenome:MGI:1934811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nucks; 2700010L10Rik; 8430423A01Rik
Summary
Predicted to enable DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including cellular glucose homeostasis; positive regulation of transcription by RNA polymerase II; and regulation of insulin receptor signaling pathway. Acts upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Located in chromatin; cytoplasm; and nucleus. Is expressed in central nervous system; embryo; liver; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 35.6), limb E14.5 (RPKM 23.1) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 E4; 1 57.22 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131838196..131864059)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131910458..131936321)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene RAB29, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800 Neighboring gene STARR-positive B cell enhancer ABC_E5800 Neighboring gene STARR-positive B cell enhancer ABC_E5801 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:133904735-133904947 Neighboring gene STARR-positive B cell enhancer ABC_E10036 Neighboring gene STARR-positive B cell enhancer ABC_E11086 Neighboring gene STARR-positive B cell enhancer ABC_E5802 Neighboring gene ELK4, member of ETS oncogene family Neighboring gene major facilitator superfamily domain containing 4A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection. Zhang Y, et al. Exp Cell Res, 2017 Jul 1. PMID 28412246
  2. Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn. Poon MW, et al. Sci Rep, 2017 Jan 20. PMID 28106169, Free PMC Article
  3. CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer. Yu J, et al. Thorac Cancer, 2022 Jan. PMID 34850570, Free PMC Article
  4. A novel, highly phosphorylated protein, of the high-mobility group type, present in a variety of proliferating and non-proliferating mammalian cells. Ostvold AC, et al. Eur J Biochem, 1985 Dec 16. PMID 3000779
  5. Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice. Yue Y, et al. Oncotarget, 2016 Sep 20. PMID 27542204, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
    Title: CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
  2. Study describes the role of NUCKS in corneal wound healing, inflammation and angiogenesis and links NUCKS to the activation of NF-kappa B and modulation of various cytokines.
    Title: Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn.
  3. in the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced thymic lymphoma, likely through the role of the NUCKS1 protein in the DNA damage response
    Title: Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice.
  4. This study demonstrates that depletion of NUCKS enhances the therapeutic efficacy of Bone marrow-derived mesenchymal stem cells for myocardial infarction via regulating the secretion of VEGFa.
    Title: Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection.
  5. Hypothalamic NUCKS plays an essential role in regulating glucose homoeostasis and insulin signaling.
    Title: Hypothalamic NUCKS regulates peripheral glucose homoeostasis.
  6. NUCKS is a physiological regulator of energy homeostasis and glucose metabolism that works by regulating chromatin accessibility and RNA polymerase II recruitment to the promoters of IR and other insulin pathway modulators.
    Title: NUCKS is a positive transcriptional regulator of insulin signaling.
  7. Results show that Nucks expression increased during the initial stages of embryonic development, and then gradually decreased until birth in all tissues except the nervous tissue and muscle fibers.
    Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
  8. The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis.
    Title: Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to X-ray ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation by host of RNA binding by virus ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation by host of viral RNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Names
JC7
nuclear ubiquitous casein and cyclin-dependent kinases substrate
nuclear, casein kinase and cyclin-dependent kinase substrate

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145804.1 → NP_001139276.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of a coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
    Source sequence(s)
    AB049825, AC115001, AC161805, AK078816, CJ075701
    Consensus CDS
    CCDS78678.1
    UniProtKB/TrEMBL
    A0A087WRY3
    Related
    ENSMUSP00000140818.2, ENSMUST00000189946.7

  2. NM_175294.3 → NP_780503.2  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 1

    See identical proteins and their annotated locations for NP_780503.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB049825, AC115001, AC161805, CJ075701
    Consensus CDS
    CCDS48356.1
    UniProtKB/Swiss-Prot
    Q80XU3, Q8BVD8
    Related
    ENSMUSP00000062576.7, ENSMUST00000062264.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131838196..131864059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XU3.1 GenPept UniProtKB/Swiss-Prot:Q80XU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous