U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp451 zinc finger protein 451 [ Mus musculus (house mouse) ]

Gene ID: 98403, updated on 18-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp451provided by MGI
Official Full Name
zinc finger protein 451provided by MGI
Primary source
MGI:MGI:2137896
See related
Ensembl:ENSMUSG00000042197 AllianceGenome:MGI:2137896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf451; COASTER; mKIAA1702; Kiaa0576-hp; 4930515K21Rik; 4933435G09Rik
Summary
Predicted to enable SUMO ligase activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of histone H3-K9 acetylation; protein sumoylation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; early conceptus; gonad; and metanephros. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 5.4) and 12 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 B; 1 12.81 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33800622..33854683, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33761541..33815602, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB23, member RAS oncogene family Neighboring gene BCL2-associated athanogene 2 Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene predicted gene 15455 Neighboring gene BEN domain containing 6 Neighboring gene predicted gene, 38471

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Antonio Urrutia G, et al. Genes Dev, 2021 Aug 1. PMID 34244292, Free PMC Article
  2. The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability. Koidl S, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27343429
  3. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. Karvonen U, et al. J Mol Biol, 2008 Oct 10. PMID 18656483
  4. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Eggenschwiler JT, et al. Nature, 2001 Jul 12. PMID 11449277
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
    Title: Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
  2. a regulatory role of ZNF451-1 in fine-tuning physiological PML levels
    Title: The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 SUMO-protein ligase ZNF451
Names
E3 SUMO-protein transferase ZNF451

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290699.1 → NP_001277628.1  E3 SUMO-protein ligase ZNF451 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC163668, AI596398, AK015797, AK030088
    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    cd18721
    Location:722 → 838
    PIN_ZNF451-like; LabA-like PIN domain of human zinc finger protein 451 and related proteins

  2. NM_001290700.1 → NP_001277629.1  E3 SUMO-protein ligase ZNF451 isoform 3

    See identical proteins and their annotated locations for NP_001277629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 3' structure and 3' terminus, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC163668, AK015797
    Consensus CDS
    CCDS69873.1
    UniProtKB/TrEMBL
    Q80TA4, Q8VCL4
    Related
    ENSMUSP00000044372.6, ENSMUST00000044455.8
    Conserved Domains (1) summary
    pfam11560
    Location:357 → 492
    LAP2alpha; Lamina-associated polypeptide 2 alpha

  3. NM_001359274.1 → NP_001346203.1  E3 SUMO-protein ligase ZNF451 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163668
    UniProtKB/TrEMBL
    Q6P6L8

  4. NM_001359275.1 → NP_001346204.1  E3 SUMO-protein ligase ZNF451 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163668
    UniProtKB/TrEMBL
    Q6P6L8

  5. NM_133817.3 → NP_598578.1  E3 SUMO-protein ligase ZNF451 isoform 1

    See identical proteins and their annotated locations for NP_598578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC163668, AI596398, AK015797, AK030088
    Consensus CDS
    CCDS14865.1
    UniProtKB/Swiss-Prot
    Q8C0P7
    UniProtKB/TrEMBL
    Q6P6L8
    Related
    ENSMUSP00000019861.7, ENSMUST00000019861.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33800622..33854683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154651.1 → XP_036010544.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:741 → 858
    PIN_11; PIN like domain

  2. XM_036154666.1 → XP_036010559.1  E3 SUMO-protein ligase ZNF451 isoform X2

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:553 → 670
    PIN_11; PIN like domain

  3. XM_030243891.2 → XP_030099751.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:741 → 858
    PIN_11; PIN like domain

RNA

  1. XR_865290.4 RNA Sequence

  2. XR_865291.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0P7.1 GenPept UniProtKB/Swiss-Prot:Q8C0P7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous