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Sh3bp4 SH3-domain binding protein 4 [ Mus musculus (house mouse) ]

Gene ID: 98402, updated on 5-Mar-2024

Summary

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Official Symbol
Sh3bp4provided by MGI
Official Full Name
SH3-domain binding protein 4provided by MGI
Primary source
MGI:MGI:2138297
See related
Ensembl:ENSMUSG00000036206 AllianceGenome:MGI:2138297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BOG25
Summary
Predicted to enable GDP-dissociation inhibitor activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; negative regulation of TOR signaling; and protein localization to lysosome. Predicted to act upstream of or within endocytosis. Predicted to be located in clathrin-coated pit; cytoplasmic vesicle; and nucleus. Predicted to be active in cytoplasm. Is expressed in cerebral cortex marginal layer and olfactory cortex marginal layer. Orthologous to human SH3BP4 (SH3 domain binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 16.2), ovary adult (RPKM 14.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 D; 1 45.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (88998061..89082940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (89070333..89155087)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34194 Neighboring gene RIKEN cDNA 1700067G17 gene Neighboring gene STARR-seq mESC enhancer starr_01654 Neighboring gene STARR-seq mESC enhancer starr_01655 Neighboring gene STARR-positive B cell enhancer ABC_E2002 Neighboring gene cytidine 5'-triphosphate synthase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01658 Neighboring gene predicted gene, 34331 Neighboring gene STARR-seq mESC enhancer starr_01661 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA C030007H22 gene Neighboring gene predicted gene, 41913

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3. Chiba S, et al. J Biochem, 2009 Mar. PMID 19122209
  2. SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization. Antas P, et al. Cell Rep, 2019 Feb 26. PMID 30811977, Free PMC Article
  3. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. Kim YM, et al. Mol Cell, 2012 Jun 29. PMID 22575674, Free PMC Article
  4. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
  5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling
    Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
  2. TTP Ser(245) is the principal target for the modulation of this protein via the AKT signalling cascade.
    Title: TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3 domain-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420833.1 → NP_001407762.1  SH3 domain-binding protein 4

    Status: VALIDATED

    Source sequence(s)
    AC126024, AC133168, AC153647
    UniProtKB/Swiss-Prot
    Q8BXV5, Q8BY95, Q8C007, Q921I6

  2. NM_001420834.1 → NP_001407763.1  SH3 domain-binding protein 4

    Status: VALIDATED

    Source sequence(s)
    AC126024, AC133168, AC153647
    UniProtKB/Swiss-Prot
    Q8BXV5, Q8BY95, Q8C007, Q921I6

  3. NM_001420835.1 → NP_001407764.1  SH3 domain-binding protein 4

    Status: VALIDATED

    Source sequence(s)
    AC126024, AC133168, AC153647
    UniProtKB/Swiss-Prot
    Q8BXV5, Q8BY95, Q8C007, Q921I6

  4. NM_133816.4 → NP_598577.1  SH3 domain-binding protein 4

    See identical proteins and their annotated locations for NP_598577.1

    Status: VALIDATED

    Source sequence(s)
    AC126024, AC133168, AC153647
    Consensus CDS
    CCDS15147.1
    UniProtKB/Swiss-Prot
    Q8BXV5, Q8BY95, Q8C007, Q921I6
    Related
    ENSMUSP00000067581.5, ENSMUST00000066279.11
    Conserved Domains (3) summary
    cd11757
    Location:59 → 110
    SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
    pfam07653
    Location:657 → 721
    SH3_2; Variant SH3 domain
    cl02517
    Location:323 → 403
    ZU5; ZU5 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    88998061..89082940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243890.2 → XP_030099750.1  SH3 domain-binding protein 4 isoform X2

    Conserved Domains (2) summary
    pfam07653
    Location:557 → 621
    SH3_2; Variant SH3 domain
    cl02517
    Location:223 → 303
    ZU5; ZU5 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921I6.1 GenPept UniProtKB/Swiss-Prot:Q921I6

Gene LinkOut

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