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Chst10 carbohydrate sulfotransferase 10 [ Mus musculus (house mouse) ]

Gene ID: 98388, updated on 18-Apr-2024

Summary

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Official Symbol
Chst10provided by MGI
Official Full Name
carbohydrate sulfotransferase 10provided by MGI
Primary source
MGI:MGI:2138283
See related
Ensembl:ENSMUSG00000026080 AllianceGenome:MGI:2138283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ST; Hnk-1st
Summary
Enables sulfotransferase activity. Acts upstream of or within learning and long-term memory. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain. Orthologous to human CHST10 (carbohydrate sulfotransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.7), CNS E18 (RPKM 7.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 17.24 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38902948..38937256, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38863867..38898177, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38752992-38753101 Neighboring gene predicted gene, 57569 Neighboring gene STARR-seq mESC enhancer starr_00700 Neighboring gene STARR-positive B cell enhancer ABC_E8770 Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene STARR-seq mESC enhancer starr_00701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38942945-38943098 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene neuromedin S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. Gurevicius K, et al. Mol Cell Neurosci, 2007 Feb. PMID 17157030
  2. HNK-1 sulfotransferase null mice express glucuronyl glycoconjugates and show normal cerebellar granule neuron migration in vivo and in vitro. Chou DK, et al. J Neurochem, 2002 Sep. PMID 12358771
  3. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. Suzuki-Anekoji M, et al. J Biol Chem, 2013 Feb 15. PMID 23269668, Free PMC Article
  4. Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration. Chou DK, et al. J Neurochem, 2004 Sep. PMID 15341523
  5. Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. Senn C, et al. Mol Cell Neurosci, 2002 Aug. PMID 12213450

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chst10 likely functions in widespread regulation of steroid hormones in vivo
    Title: In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.
  2. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.
    Title: Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
  3. This study conclude that in ST-/- mice which show morphological, electrophysiological and behavioural abnormalities, the ECS is reduced and its geometry altered.
    Title: Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables HNK-1 sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 10
Names
HNK-1 sulfotransferase
HNK1ST
NP_001355709.1
NP_660124.3
XP_006496427.1
XP_030099743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368780.1 → NP_001355709.1  carbohydrate sulfotransferase 10

    Status: VALIDATED

    Source sequence(s)
    AC101277, AC124699
    UniProtKB/Swiss-Prot
    Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
    UniProtKB/TrEMBL
    A0A0A6YVW5
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

  2. NM_145142.3 → NP_660124.3  carbohydrate sulfotransferase 10

    Status: VALIDATED

    Source sequence(s)
    AC101277, AC124699
    Consensus CDS
    CCDS14901.1
    UniProtKB/Swiss-Prot
    Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
    UniProtKB/TrEMBL
    A0A0A6YVW5
    Related
    ENSMUSP00000027249.8, ENSMUST00000027249.13
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    38902948..38937256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496364.5 → XP_006496427.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_006496427.1

    UniProtKB/TrEMBL
    A0A0A6YVW5, A2RSS2
    Conserved Domains (1) summary
    pfam03567
    Location:134 → 366
    Sulfotransfer_2; Sulfotransferase family

  2. XM_030243883.1 → XP_030099743.1  carbohydrate sulfotransferase 10 isoform X2

    UniProtKB/Swiss-Prot
    Q6PGK7, Q8BKU3, Q8BL08, Q8R2Y5, Q91Y40
    UniProtKB/TrEMBL
    A0A0A6YVW5
    Conserved Domains (1) summary
    pfam03567
    Location:116 → 348
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PGK7.2 GenPept UniProtKB/Swiss-Prot:Q6PGK7

Gene LinkOut

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