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Smap1 small ArfGAP 1 [ Mus musculus (house mouse) ]

Gene ID: 98366, updated on 5-Mar-2024

Summary

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Official Symbol
Smap1provided by MGI
Official Full Name
small ArfGAP 1provided by MGI
Primary source
MGI:MGI:2138261
See related
Ensembl:ENSMUSG00000026155 AllianceGenome:MGI:2138261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700056O10Rik; 4921514B13Rik; 4921525H11Rik
Summary
Enables GTPase activator activity and clathrin binding activity. Acts upstream of or within positive regulation of erythrocyte differentiation and regulation of clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in embryo. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 50.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A5; 1 9.79 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23883925..23961462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23844825..23922381, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_00435 Neighboring gene predicted gene 28822 Neighboring gene STARR-seq mESC enhancer starr_00436 Neighboring gene STARR-seq mESC enhancer starr_00437 Neighboring gene STARR-positive B cell enhancer ABC_E4306 Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene predicted gene, 30756

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. Kon S, et al. J Clin Invest, 2013 Mar. PMID 23434593, Free PMC Article
  2. Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. Sumiyoshi M, et al. FEBS Lett, 2015 Sep 14. PMID 26296315
  3. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. Sato Y, et al. J Biochem, 1998 Jul. PMID 9644265
  4. A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis. Tanabe K, et al. Mol Biol Cell, 2005 Apr. PMID 15659652, Free PMC Article
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
stromal membrane-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290683.2 → NP_001277612.1  stromal membrane-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001277612.1

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC153649
    Consensus CDS
    CCDS69870.1
    UniProtKB/TrEMBL
    D3YVX4
    Related
    ENSMUSP00000117875.2, ENSMUST00000129254.8

  2. NM_001357395.2 → NP_001344324.1  stromal membrane-associated protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC123790, AC153649
    Conserved Domains (2) summary
    pfam01412
    Location:20 → 120
    ArfGap; Putative GTPase activating protein for Arf
    pfam09606
    Location:343 → 451
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. NM_028534.4 → NP_082810.1  stromal membrane-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082810.1

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC123790, AC153649
    Consensus CDS
    CCDS14851.1
    UniProtKB/Swiss-Prot
    Q497I6, Q68EF3, Q91VZ6
    Related
    ENSMUSP00000027339.8, ENSMUST00000027339.14
    Conserved Domains (1) summary
    pfam01412
    Location:20 → 120
    ArfGap; Putative GTPase activating protein for Arf

RNA

  1. NR_110972.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC153649
    Related
    ENSMUST00000149737.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    23883925..23961462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243880.2 → XP_030099740.1  stromal membrane-associated protein 1 isoform X1

    Conserved Domains (1) summary
    cl28907
    Location:1 → 35
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VZ6.1 GenPept UniProtKB/Swiss-Prot:Q91VZ6

Gene LinkOut

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