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Smap1 small ArfGAP 1 [ Mus musculus (house mouse) ]

Gene ID: 98366, updated on 9-Dec-2024

Summary

Official Symbol
Smap1provided by MGI
Official Full Name
small ArfGAP 1provided by MGI
Primary source
MGI:MGI:2138261
See related
Ensembl:ENSMUSG00000026155 AllianceGenome:MGI:2138261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700056O10Rik; 4921514B13Rik; 4921525H11Rik
Summary
Enables GTPase activator activity and clathrin binding activity. Acts upstream of or within positive regulation of erythrocyte differentiation and regulation of clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in embryo. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 50.0), CNS E18 (RPKM 24.8) and 28 other tissues See more
Orthologs
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Genomic context

See Smap1 in Genome Data Viewer
Location:
1 A5; 1 9.79 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23883925..23961462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23844825..23922381, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_00435 Neighboring gene predicted gene 28822 Neighboring gene STARR-seq mESC enhancer starr_00436 Neighboring gene STARR-seq mESC enhancer starr_00437 Neighboring gene STARR-positive B cell enhancer ABC_E4306 Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene family with sequence similarity 135, member A Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene predicted gene, 30756

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity  
enables GTPase activator activity PubMed 
enables clathrin binding PubMed 
enables metal ion binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in plasma membrane  

General protein information

Preferred Names
stromal membrane-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290683.2NP_001277612.1  stromal membrane-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001277612.1

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC153649
    Consensus CDS
    CCDS69870.1
    UniProtKB/TrEMBL
    D3YVX4
    Related
    ENSMUSP00000117875.2, ENSMUST00000129254.8
  2. NM_001357395.2NP_001344324.1  stromal membrane-associated protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC123790, AC153649
    Conserved Domains (2) summary
    pfam01412
    Location:20120
    ArfGap; Putative GTPase activating protein for Arf
    pfam09606
    Location:343451
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. NM_028534.4NP_082810.1  stromal membrane-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082810.1

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC123790, AC153649
    Consensus CDS
    CCDS14851.1
    UniProtKB/Swiss-Prot
    Q497I6, Q68EF3, Q91VZ6
    Related
    ENSMUSP00000027339.8, ENSMUST00000027339.14
    Conserved Domains (1) summary
    pfam01412
    Location:20120
    ArfGap; Putative GTPase activating protein for Arf

RNA

  1. NR_110972.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121857, AC153649
    Related
    ENSMUST00000149737.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    23883925..23961462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243880.2XP_030099740.1  stromal membrane-associated protein 1 isoform X1

    Conserved Domains (1) summary
    cl28907
    Location:135
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
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