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Serpinb6c serine (or cysteine) peptidase inhibitor, clade B, member 6c [ Mus musculus (house mouse) ]

Gene ID: 97848, updated on 8-Feb-2024

Summary

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Official Symbol
Serpinb6cprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B, member 6cprovided by MGI
Primary source
MGI:MGI:2145481
See related
Ensembl:ENSMUSG00000052180 AllianceGenome:MGI:2145481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPIC; SPI3C; ovalbumin
Summary
Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in esophagus epithelium; ovary; ovary follicle; and testis. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
13 A3.3; 13 13.99 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34063799..34089709, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33879816..33905726, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 94 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e Neighboring gene STARR-seq mESC enhancer starr_34130 Neighboring gene STARR-seq mESC enhancer starr_34131 Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene N-ribosyldihydronicotinamide quinone reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Charron Y, et al. Mol Reprod Dev, 2006 Jan. PMID 16175637
  2. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
  3. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365
  4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine proteinase inhibitor member 6C
Names
serine (or cysteine) proteinase inhibitor, clade B, member 6c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382852.1 → NP_001369781.1  serine proteinase inhibitor member 6C

    Status: VALIDATED

    Source sequence(s)
    AL450406
    UniProtKB/TrEMBL
    Q6P6K7, W4VSP4
    Related
    ENSMUSP00000105902.3, ENSMUST00000110273.9
    Conserved Domains (1) summary
    cl38926
    Location:2 → 379
    serpin; SERine Proteinase INhibitors (serpin) family

  2. NM_148942.3 → NP_683744.2  serine proteinase inhibitor member 6C

    See identical proteins and their annotated locations for NP_683744.2

    Status: VALIDATED

    Source sequence(s)
    AL450406, BC062169
    Consensus CDS
    CCDS49227.1
    UniProtKB/TrEMBL
    Q6P6K7, W4VSP4
    Related
    ENSMUSP00000127619.2, ENSMUST00000172184.2
    Conserved Domains (1) summary
    cl38926
    Location:2 → 379
    serpin; SERine Proteinase INhibitors (serpin) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    34063799..34089709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158233.1 → XP_036014126.1  serine proteinase inhibitor member 6C isoform X1

    UniProtKB/TrEMBL
    Q6P6K7
    Conserved Domains (1) summary
    cl38926
    Location:24 → 346
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version

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