DCAF1 DDB1 and CUL4 associated factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCAF1provided by HGNC
Official Full Name: DDB1 and CUL4 associated factor 1provided by HGNC
Primary source: HGNC:HGNC:30911
See related: Ensembl:ENSG00000145041 MIM:617259; AllianceGenome:HGNC:30911
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RIP; VPRBP
Summary: Enables estrogen receptor binding activity and histone kinase activity (H2A-T120 specific). Involved in cell competition in a multicellular organism; histone H2A-T120 phosphorylation; and negative regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. Part of Cul4-RING E3 ubiquitin ligase complex. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 27.5), thyroid (RPKM 8.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p21.2

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (51395867..51505639, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (51426284..51536063, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (51433298..51534031, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability.
Title: CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability.
Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer.
Title: Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer.
VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer.
Title: VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer.
VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer.
Title: VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer.
The CRL4(DCAF1) cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Title: The CRL4(DCAF1) cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.
Title: Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.
VprBP mitigates TGF-beta and Activin signaling by promoting Smurf1-mediated type I receptor degradation.
Title: VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation.
lentiviral accessory protein Vpx exploits DCAF1 to counteract Vpx-mediated SAMHD1 degradation
Title: Determinants of lentiviral Vpx-CRL4 E3 ligase-mediated SAMHD1 degradation in the substrate adaptor protein DCAF1.
HIV-1 Vpr degrades TET2 by CRL4 E3 ligase to sustain IL-6 expression to enhance viral replication and disease progression.
Title: Vpr Targets TET2 for Degradation by CRL4(VprBP) E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication.
Data suggest that HIV-1 vpr mediates polyubiquitination of HLTF by directly loading it onto C-terminal WD40 domain of DCAF1 in complex the CRL4, an E3 ubiquitin ligase. (vpr = vpr gene product of Human immunodeficiency virus 1; HLTF = human helicase like transcription factor; DCAF1 = human Vpr (HIV-1) binding protein; CRL4 = human E3 ubiquitin ligase CRL4)
Title: HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 Vpr downregulates HLTF in a DCAF1-dependent manner in HeLa, Jurkat T and primary T cells and primary macrophages as shown through DCAF1 siRNA knockdown	PubMed
Knockdown of Vpr (HIV-1) binding protein (VPRBP) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation	PubMed
	env	VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells	PubMed
Envelope surface glycoprotein gp160, precursor	env	DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells	PubMed
Envelope transmembrane glycoprotein gp41	env	Env-dependent MDM/T cell viral synapse formation is facilitated by Vpr/VPRBP (DCAF1) cooperation	PubMed
	env	VPRBP (DCAF1) is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells	PubMed
Pr55(Gag)	gag	DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env/gp160 (gp120/gp41) expression in MDM cells	PubMed
Vpr	vpr	Vpr-dependent HIV-1 spread from MDMs to CD4+ T lymphocytes requires VPRBP (DCAF1)	PubMed
	vpr	Vpr cooperates with VPRBP (DCAF1) to increase T lymphocyte HIV-1 infection by counteracting type I interferon inducible restriction of Env-dependent viral synapse formation between MDM and T cells	PubMed
	vpr	HIV-1 Vpr binds DCAF1; Vpr E25,L26 and a2 E29 form a small pocket for DCAF1 W1156 binding (the N-terminal tail of Vpr wraps around the propeller, following small groove between two blades)	PubMed
	vpr	HIV-1 Vpr binds DCAF1; residues R62, Q65 and R73 on a3 of Vpr form hydrogen bonds with E1088, S1136 and T1139 of DCAF1, respectively. Vpr F69 inserts in a small hydrophobic pocket formed by DCAF1 A1137, F1330 and F1355	PubMed
	vpr	DCAF1 is required for HIV-1 Vpr to increase virion production (Gag/pr55 levels) and Env gp160 (gp120/gp41) expression in MDM cells	PubMed
	vpr	Residues N1135 and W1156 in DCAF1 are required for its binding to the SIVmac Vpx Q76 residue but not with HIV-1 Vpr	PubMed
	vpr	The minimal domain (residues 1041-1393) of DCAF1, which contains the motifs required for proper recruitment of both Vpr and DDB1, is not sufficient to support Vpr-mediated G2 arrest activity	PubMed
	vpr	The two WD-40 motifs (residues 1041-1393) in the C-terminal region of DCAF1 form a complex with HIV-1 Vpr and DDB1. The double mutant DCAF1 R1247/1283A completely abolishes its ability to bind both Vpr and DDB1	PubMed
	vpr	The interaction of HIV-1 Vpr with the EDVP E3 ligase complex (EDD, DDB1, and VPRBP) promotes Vpr-mediated downregulation of TERT protein	PubMed
	vpr	HIV-1 Vpr directly interacts with the C-terminal SLX1 binding domain of SLX4 and recruits VPRBP to the SSE regulator complex SLX4	PubMed
	vpr	Co-immunoprecipitation and glycerol-gradient sedimentation demonstrate that HIV-1 Vpr, VPRBP, DDB1, SLX4, MUS81, EME1, ERCC1, and ERCC4 form a complex	PubMed
	vpr	HIV-1 Vpr-mediated UNG2 degradation and constitutive UNG2 turnover are dependent on DCAF1 or DDB1 but not on CUL4a or CUL4B in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells	PubMed
	vpr	HIV-1 Vpr complexes with DCAF1, DDB1, CUL4A, CUL4B, and UNG2 proteins in the cullin4 (CUL4)-containing ubiquitin ligase complex in HEK293T cells	PubMed
	vpr	Mutation of Trp18, Gln65, and His71 residues in HIV-1 Vpr abrogates DDB1-DCAF1 binding and Vpr-induced cell cycle arrest	PubMed
	vpr	VPRBP is required for HIV-1 Vpr-mediated activation of the SLX4 complex and modulation of MUS81 levels. The interaction between Vpr and VPRBP is involved in MUS81 ubiquitination	PubMed
	vpr	HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex	PubMed
	vpr	HIV-1 Vpr induces the degradation of ZIP/sZIP through the DCAF1 ubiquitin ligase, while VprQ65R mutant impairs the Vpr-induced degradation of ZIP/sZIP	PubMed
	vpr	HIV-1 Vpr co-localizes with the Cul4A ubiquitin ligase complex (Cul4A, DCAF1, and DDB1) in the cellular chromatin compartment	PubMed
	vpr	HIV-1 Vpr induces the degradation of APOBEC3G through VprBP binding and participation of the proteasome, leading to a reduction in APOBEC3G encapsidation into virions	PubMed
	vpr	The interaction of HIV-1 Vpr with VprBP enhances HIV-1 infection in monocyte-derived dendritic cells	PubMed
	vpr	HIV-1 Vpr significantly downregulates expression level of MFN2 in the mitochondria via VprBP-DDB1-CUL4A ubiquitin ligase in a proteasome-dependent manner	PubMed
	vpr	Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex	PubMed
	vpr	W54R/S79A Vpr mutant impairs to interact with UNG2, but is still able to recruit DCAF1. Three G2 arrest-defective Vpr mutants, Q65R, K27M, and S79A, can interact with DCAF1	PubMed
	vpr	A highly conserved 18WxxxxFxxFxxxAFxH33 motif of the HIV-1 Vpr binds to DCAF1, leading to Vpr-induced G2 arrest. Vpr mutants L22S/L23S and V30S/V31S impair the ability to induce G2 arrest	PubMed
	vpr	HIV-1 Vpr binds DCAF1 and activates the DNA damage response in renal tubule epithelial cells, in which gamma H2AX-positive nuclei are abundant compared to the control	PubMed
	vpr	DCAF1 interacts with DDB1 as well as the Vpr-UNG2 complex, which leads to polyubiquitination of UNG2 via Vpr	PubMed
	vpr	Recruitment of a catalytically active CRL4A (VPRBP) complex is required to observe HIV-1 Vpr-interacting unknown cellular ubiquitinated proteins. Phosphorylation of H2AX requires Vpr-induced K48 residue polyubiquitination	PubMed
	vpr	HIV-1 Vpr forms nuclear foci containing VPRBP and partially co-localizes with DNA repair foci components 53BP1 and phosphorylated RPA32	PubMed
	vpr	HIV-1 Vpr(Q65R) mutant fails to bind DDB1 and VprBP, and also fails to induce G2 arrest	PubMed
	vpr	The interaction between Vpr and the Cul4A-DDB1-VprBP complex is required for the induction of G2 arrest	PubMed
	vpr	HIV-1 Vpr binds a ternary complex composed of DDB1, DDA1, and VprBP, and modulates the interaction between the DDB1-DDA1-VprBP complex and other factors	PubMed
	vpr	The leucine/isoleucine-rich domain of HIV-1 Vpr (amino acids 60-81) mediates binding of Vpr to the C-terminal half of VprBP (amino acids 636-1507), resulting in the cytoplasmic retention of Vpr	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH41778 (e-PCR)
- UniSTS:15364

SHGC-57673 (e-PCR)
- UniSTS:18440

D3S2871E (e-PCR)
- UniSTS:83465

D3S3947 (e-PCR)
- UniSTS:81164

RH93354 (e-PCR)
- UniSTS:92968

D3S4443 (e-PCR)
- UniSTS:474194

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AT120 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in V(D)J recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in post-translational protein modification	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 1

Names: HIV-1 Vpr-binding protein; Vpr (HIV-1) binding protein; Vpr-binding protein; protein VPRBP; serine/threonine-protein kinase VPRBP; vpr-interacting protein

NP_001165375.1

EC 2.7.11.1

NP_001336097.1

EC 2.7.11.1

NP_001336098.1

EC 2.7.11.1

NP_001336099.1

EC 2.7.11.1

NP_001336100.1

EC 2.7.11.1

NP_001374507.1

EC 2.7.11.1

NP_001374508.1

EC 2.7.11.1

NP_001374509.1

EC 2.7.11.1

NP_001374510.1

EC 2.7.11.1

NP_001374511.1

EC 2.7.11.1

NP_001374512.1

EC 2.7.11.1

NP_055518.1

EC 2.7.11.1

XP_005276810.1

EC 2.7.11.1

XP_005276812.1

EC 2.7.11.1

XP_011532575.1

EC 2.7.11.1

XP_011532577.1

EC 2.7.11.1

XP_016863036.1

EC 2.7.11.1

XP_016863038.1

EC 2.7.11.1

XP_047305225.1

EC 2.7.11.1

XP_047305226.1

EC 2.7.11.1

XP_047305227.1

EC 2.7.11.1

XP_047305228.1

EC 2.7.11.1

XP_047305229.1

EC 2.7.11.1

XP_047305230.1

EC 2.7.11.1

XP_047305231.1

EC 2.7.11.1

XP_047305232.1

EC 2.7.11.1

XP_047305233.1

EC 2.7.11.1

XP_047305234.1

EC 2.7.11.1

XP_047305235.1

EC 2.7.11.1

XP_047305236.1

EC 2.7.11.1

XP_047305237.1

EC 2.7.11.1

XP_047305238.1

EC 2.7.11.1

XP_047305239.1

EC 2.7.11.1

XP_054204493.1

EC 2.7.11.1

XP_054204494.1

EC 2.7.11.1

XP_054204495.1

EC 2.7.11.1

XP_054204496.1

EC 2.7.11.1

XP_054204497.1

EC 2.7.11.1

XP_054204498.1

EC 2.7.11.1

XP_054204499.1

EC 2.7.11.1

XP_054204500.1

EC 2.7.11.1

XP_054204501.1

EC 2.7.11.1

XP_054204502.1

EC 2.7.11.1

XP_054204503.1

EC 2.7.11.1

XP_054204504.1

EC 2.7.11.1

XP_054204505.1

EC 2.7.11.1

XP_054204506.1

EC 2.7.11.1

XP_054204507.1

EC 2.7.11.1

XP_054204508.1

EC 2.7.11.1

XP_054204509.1

EC 2.7.11.1

XP_054204510.1

EC 2.7.11.1

XP_054204511.1

EC 2.7.11.1

XP_054204512.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171904.2 → NP_001165375.1 DDB1- and CUL4-associated factor 1 isoform 2

See identical proteins and their annotated locations for NP_001165375.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR and uses and alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. Variants 2 and 12 both encode the same isoform (2).

Source sequence(s)

AB018343, AC092037, BC110371, BP222559, CR986856

Consensus CDS

CCDS74944.1

UniProtKB/Swiss-Prot

Q9Y4B6

Related

ENSP00000421724.2, ENST00000504652.5

Conserved Domains (3) summary

sd00039
Location:1096 → 1132

7WD40; WD40 repeat [structural motif]

NF033760
Location:873 → 952

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1092 → 1310

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001349168.2 → NP_001336097.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001349169.2 → NP_001336098.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001349170.2 → NP_001336099.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 3-5, and 8-11 all encode the same isoform (1).

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001349171.2 → NP_001336100.1 DDB1- and CUL4-associated factor 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' and 3' UTR and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1. Variants 6 and 13 both encode the same isoform (3).

Source sequence(s)

AC092037, AC233756

Conserved Domains (3) summary

sd00039
Location:1015 → 1051

7WD40; WD40 repeat [structural motif]

NF033760
Location:792 → 871

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1011 → 1229

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387578.1 → NP_001374507.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387579.1 → NP_001374508.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Related

ENSP00000506880.1, ENST00000684031.1

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387580.1 → NP_001374509.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387581.1 → NP_001374510.1 DDB1- and CUL4-associated factor 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387582.1 → NP_001374511.1 DDB1- and CUL4-associated factor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Consensus CDS

CCDS74944.1

Conserved Domains (3) summary

sd00039
Location:1096 → 1132

7WD40; WD40 repeat [structural motif]

NF033760
Location:873 → 952

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1092 → 1310

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001387583.1 → NP_001374512.1 DDB1- and CUL4-associated factor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

Conserved Domains (3) summary

sd00039
Location:1015 → 1051

7WD40; WD40 repeat [structural motif]

NF033760
Location:792 → 871

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1011 → 1229

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_014703.3 → NP_055518.1 DDB1- and CUL4-associated factor 1 isoform 1

See identical proteins and their annotated locations for NP_055518.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3-5, and 8-11 all encode the same isoform (1).

Source sequence(s)

AB018343, AC092037, CR986856

Consensus CDS

CCDS74943.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

NR_146065.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC092037, AC233756
NR_170668.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC092037, AC233756

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

51395867..51505639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449275.1 → XP_047305231.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_047449269.1 → XP_047305225.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Related

ENSP00000393183.2, ENST00000423656.5
XM_047449278.1 → XP_047305234.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_047449270.1 → XP_047305226.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_047449274.1 → XP_047305230.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_047449282.1 → XP_047305238.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_047449277.1 → XP_047305233.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_047449276.1 → XP_047305232.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_017007549.3 → XP_016863038.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047449271.1 → XP_047305227.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_005276755.6 → XP_005276812.1 DDB1- and CUL4-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_005276812.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047449273.1 → XP_047305229.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_047449272.1 → XP_047305228.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_017007547.3 → XP_016863036.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011534275.4 → XP_011532577.1 DDB1- and CUL4-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011532577.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011534273.4 → XP_011532575.1 DDB1- and CUL4-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_011532575.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047449279.1 → XP_047305235.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_047449280.1 → XP_047305236.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_047449281.1 → XP_047305237.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_005276753.6 → XP_005276810.1 DDB1- and CUL4-associated factor 1 isoform X1

See identical proteins and their annotated locations for XP_005276810.1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6

Conserved Domains (3) summary

sd00039
Location:1097 → 1133

7WD40; WD40 repeat [structural motif]

NF033760
Location:874 → 953

gliding_GltG; adventurous gliding motility protein GltG

cl29593
Location:1093 → 1311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047449283.1 → XP_047305239.1 DDB1- and CUL4-associated factor 1 isoform X4

RNA

XR_007095776.1 RNA Sequence
XR_007095774.1 RNA Sequence
XR_007095775.1 RNA Sequence
XR_007095773.1 RNA Sequence
XR_007095777.1 RNA Sequence
XR_007095778.1 RNA Sequence
XR_007095772.1 RNA Sequence
XR_001740385.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

51426284..51536063 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348529.1 → XP_054204504.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_054348518.1 → XP_054204493.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348532.1 → XP_054204507.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_054348520.1 → XP_054204495.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348528.1 → XP_054204503.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_054348536.1 → XP_054204511.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_054348531.1 → XP_054204506.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_054348530.1 → XP_054204505.1 DDB1- and CUL4-associated factor 1 isoform X2
XM_054348519.1 → XP_054204494.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348521.1 → XP_054204496.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348522.1 → XP_054204497.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348526.1 → XP_054204501.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348524.1 → XP_054204499.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348523.1 → XP_054204498.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348525.1 → XP_054204500.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348533.1 → XP_054204508.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_054348534.1 → XP_054204509.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_054348535.1 → XP_054204510.1 DDB1- and CUL4-associated factor 1 isoform X3
XM_054348527.1 → XP_054204502.1 DDB1- and CUL4-associated factor 1 isoform X1

UniProtKB/Swiss-Prot

Q2YD74, Q8TBD9, Q9HCA1, Q9UG37, Q9Y4B6
XM_054348537.1 → XP_054204512.1 DDB1- and CUL4-associated factor 1 isoform X4