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Nmd3 NMD3 ribosome export adaptor [ Mus musculus (house mouse) ]

Gene ID: 97112, updated on 5-Mar-2024

Summary

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Official Symbol
Nmd3provided by MGI
Official Full Name
NMD3 ribosome export adaptorprovided by MGI
Primary source
MGI:MGI:2140103
See related
Ensembl:ENSMUSG00000027787 AllianceGenome:MGI:2140103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein-macromolecule adaptor activity and ribosomal large subunit binding activity. Predicted to be involved in several processes, including positive regulation of protein binding activity; positive regulation of protein localization to nucleolus; and ribosomal large subunit export from nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.4), CNS E11.5 (RPKM 10.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E1- E2; 3 32.25 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (69629354..69656380)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69722055..69749047)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57714 Neighboring gene STARR-seq mESC enhancer starr_07930 Neighboring gene STARR-positive B cell enhancer ABC_E9552 Neighboring gene ribosomal protein L32, pseudogene Neighboring gene predicted gene, 52662 Neighboring gene STARR-seq mESC enhancer starr_07931 Neighboring gene ribosome production factor 2 homolog pseudogene Neighboring gene serine palmitoyltransferase, small subunit B Neighboring gene predicted gene, 52608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the ligands of protein interaction domains through a functional approach. Caratù G, et al. Mol Cell Proteomics, 2007 Feb. PMID 17124247
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of RNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
60S ribosomal export protein NMD3
Names
NMD3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411212.1 → NP_001398141.1  60S ribosomal export protein NMD3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  2. NM_001411213.1 → NP_001398142.1  60S ribosomal export protein NMD3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  3. NM_001411214.1 → NP_001398143.1  60S ribosomal export protein NMD3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  4. NM_001411215.1 → NP_001398144.1  60S ribosomal export protein NMD3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  5. NM_001411216.1 → NP_001398145.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  6. NM_001411217.1 → NP_001398146.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  7. NM_001411218.1 → NP_001398147.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  8. NM_001411219.1 → NP_001398148.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  9. NM_001411220.1 → NP_001398149.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  10. NM_001411221.1 → NP_001398150.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  11. NM_001411222.1 → NP_001398151.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  12. NM_001411223.1 → NP_001398152.1  60S ribosomal export protein NMD3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  13. NM_001411224.1 → NP_001398153.1  60S ribosomal export protein NMD3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  14. NM_001411225.1 → NP_001398154.1  60S ribosomal export protein NMD3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790

  15. NM_133787.3 → NP_598548.1  60S ribosomal export protein NMD3 isoform 1

    See identical proteins and their annotated locations for NP_598548.1

    Status: VALIDATED

    Source sequence(s)
    AC115035, AC162790
    Consensus CDS
    CCDS17407.1
    UniProtKB/Swiss-Prot
    Q3UPR1, Q8BM61, Q99L48
    Related
    ENSMUSP00000029358.9, ENSMUST00000029358.15
    Conserved Domains (1) summary
    pfam04981
    Location:17 → 246
    NMD3; NMD3 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    69629354..69656380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L48.1 GenPept UniProtKB/Swiss-Prot:Q99L48

Gene LinkOut

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