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WSCD2 WSC domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9671, updated on 5-Mar-2024

Summary

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Official Symbol
WSCD2provided by HGNC
Official Full Name
WSC domain containing 2provided by HGNC
Primary source
HGNC:HGNC:29117
See related
Ensembl:ENSG00000075035 MIM:619253; AllianceGenome:HGNC:29117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 7.6), brain (RPKM 4.6) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
12q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108129288..108250537)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108097493..108218761)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108523065..108644314)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4824 Neighboring gene uncharacterized LOC105369964 Neighboring gene programmed cell death 2 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr12:108434034-108434567 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4825 Neighboring gene uncharacterized LOC124903076 Neighboring gene uncharacterized LOC105369965 Neighboring gene uncharacterized LOC124903077 Neighboring gene uncharacterized LOC124903078 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3G-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Lo MT, et al. Nat Genet, 2017 Jan. PMID 27918536, Free PMC Article
  2. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. Kato N, et al. Hum Mol Genet, 2008 Feb 15. PMID 18003638
  3. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. Greenwood TA, et al. Biol Psychiatry, 2012 Aug 15. PMID 22365631, Free PMC Article
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Oct 30. PMID 9872452
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Navarini AA, et al. Nat Commun, 2014 Jun 13. PMID 24927181

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WSCD2 polymorphism is associated with extraversion.
    Title: Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ40750, FLJ54414, KIAA0789, MGC117165, MGC168300, MGC168301, DKFZp686E1293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sialate:O-sulfotransferase 2
Names
WSC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304447.2 → NP_001291376.1  sialate:O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_001291376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009729, BX647283
    Consensus CDS
    CCDS41828.1
    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Related
    ENSP00000331933.4, ENST00000332082.8
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_014653.4 → NP_055468.2  sialate:O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_055468.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009729, BC110330, BX647283, DA095713
    Consensus CDS
    CCDS41828.1
    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Related
    ENSP00000448047.1, ENST00000547525.6
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108129288..108250537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020244.2 → XP_016875733.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_017020243.2 → XP_016875732.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_017020248.2 → XP_016875737.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  4. XM_017020252.2 → XP_016875741.1  sialate:O-sulfotransferase 2 isoform X2

    Conserved Domains (2) summary
    smart00321
    Location:130 → 224
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:315 → 407
    Sulfotransfer_3; Sulfotransferase family

  5. XM_017020250.3 → XP_016875739.1  sialate:O-sulfotransferase 2 isoform X2

    Conserved Domains (2) summary
    smart00321
    Location:130 → 224
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:315 → 407
    Sulfotransfer_3; Sulfotransferase family

  6. XM_047429914.1 → XP_047285870.1  sialate:O-sulfotransferase 2 isoform X3

  7. XM_017020245.2 → XP_016875734.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  8. XM_017020251.3 → XP_016875740.1  sialate:O-sulfotransferase 2 isoform X2

    Conserved Domains (2) summary
    smart00321
    Location:130 → 224
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:315 → 407
    Sulfotransfer_3; Sulfotransferase family

  9. XM_017020247.2 → XP_016875736.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  10. XM_017020246.3 → XP_016875735.1  sialate:O-sulfotransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RN48, B4DES1, Q2TBF2, Q8IY35, Q9Y4B7
    Related
    ENSP00000447272.1, ENST00000549903.1
    Conserved Domains (2) summary
    smart00321
    Location:127 → 219
    WSC; present in yeast cell wall integrity and stress response component proteins
    cl21551
    Location:415 → 507
    Sulfotransfer_1; Sulfotransferase domain

  11. XM_047429913.1 → XP_047285869.1  sialate:O-sulfotransferase 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108097493..108218761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373880.1 → XP_054229855.1  sialate:O-sulfotransferase 2 isoform X1

  2. XM_054373879.1 → XP_054229854.1  sialate:O-sulfotransferase 2 isoform X1

  3. XM_054373884.1 → XP_054229859.1  sialate:O-sulfotransferase 2 isoform X1

  4. XM_054373888.1 → XP_054229863.1  sialate:O-sulfotransferase 2 isoform X2

  5. XM_054373885.1 → XP_054229860.1  sialate:O-sulfotransferase 2 isoform X2

  6. XM_054373889.1 → XP_054229864.1  sialate:O-sulfotransferase 2 isoform X3

  7. XM_054373881.1 → XP_054229856.1  sialate:O-sulfotransferase 2 isoform X1

  8. XM_054373886.1 → XP_054229861.1  sialate:O-sulfotransferase 2 isoform X2

  9. XM_054373883.1 → XP_054229858.1  sialate:O-sulfotransferase 2 isoform X1

  10. XM_054373882.1 → XP_054229857.1  sialate:O-sulfotransferase 2 isoform X1

  11. XM_054373887.1 → XP_054229862.1  sialate:O-sulfotransferase 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TBF2.2 GenPept UniProtKB/Swiss-Prot:Q2TBF2

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