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GOSR1 golgi SNAP receptor complex member 1 [ Homo sapiens (human) ]

Gene ID: 9527, updated on 3-Apr-2024

Summary

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Official Symbol
GOSR1provided by HGNC
Official Full Name
golgi SNAP receptor complex member 1provided by HGNC
Primary source
HGNC:HGNC:4430
See related
Ensembl:ENSG00000108587 MIM:604026; AllianceGenome:HGNC:4430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P28; GS28; GOS28; GOLIM2; GOS-28; GOS28/P28
Summary
This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.3), kidney (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30477408..30527592)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31422038..31472230)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28804426..28854610)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11994 Neighboring gene RNA, U6 small nuclear 990, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28705846-28706773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28715045-28715730 Neighboring gene Sharpr-MPRA regulatory region 2970 Neighboring gene carboxypeptidase D Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:28732022-28732693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11999 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:28863435-28863984 Neighboring gene arachidonate 12-lipoxygenase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28868427-28868928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28878036-28878566 Neighboring gene TBC1 domain family member 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases. Li M, et al. Curr Protein Pept Sci, 2023. PMID 36924089
  2. Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers. Lee SH, et al. Int J Med Sci, 2017. PMID 28638266, Free PMC Article
  3. Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers. Cho U, et al. PLoS One, 2016. PMID 27611086, Free PMC Article
  4. Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport. Fusella A, et al. Traffic, 2013 May. PMID 23387339
  5. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53. Sun NK, et al. Biochem J, 2012 Jun 1. PMID 22397410

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases.
    Title: Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases.
  2. these results indicate that GS28 nuclear predominant expression could serve as a prognostic marker for colorectal cancer (CRC) and may help in identifying aggressive forms of CRC
    Title: Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers.
  3. High nuclear expression of GS28 is associated with poor prognosis in early-stage cervical cancer patients. GS28 might be a novel prognostic marker and a potential therapeutic target in cervical cancer treatment.
    Title: Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Worse Prognosis in Cervical Cancers.
  4. Golgi vesicles, presumably with COPI, serve to inhibit intra-Golgi transport by the extraction of GS27 and GS28 from the Golgi cisternae, which blocks the formation of inter-cisternal connections
    Title: Segregation of the Qb-SNAREs GS27 and GS28 into Golgi vesicles regulates intra-Golgi transport.
  5. GS28 may potentiate cells to DNA-damage-induced apoptosis by inhibiting the ubiquitination and degradation of p53.
    Title: Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53.
  6. ORP7 negatively regulates GS28 protein stability via sequestration of GATE-16, and may mediate the effect of 25-OH on GS28 and Golgi function.
    Title: OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability.
  7. Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development.
    Title: Microarray analysis of differentially expressed genes in vaginal tissues in postmenopausal women. The role of stress urinary incontinence.
  8. Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport.
    Title: GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.
  9. RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18.
    Title: RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inter-Golgi cisterna vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi medial cisterna IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in transport vesicle TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
Golgi SNAP receptor complex member 1
Names
28 kDa Golgi SNARE protein
28 kDa cis-Golgi SNARE p28
Golgi SNARE 28 kDa
cis-golgi SNARE
golgi integral membrane protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007024.2 → NP_001007025.1  Golgi SNAP receptor complex member 1 isoform 3

    See identical proteins and their annotated locations for NP_001007025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in one exon and lacks a small segment in another exon in the 5' region, as compared to variant 1. It uses a downstream AUG start codon, and the encoded isoform 3 thus has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC011840, AF047438, AK000606, AK074298, BC040072, BC040471, BG654545, CB054624
    Consensus CDS
    CCDS45644.1
    UniProtKB/Swiss-Prot
    O95249
    Related
    ENSP00000462638.1, ENST00000467337.6
    Conserved Domains (1) summary
    cd15864
    Location:95 → 160
    SNARE_GS28; SNARE motif of GS28

  2. NM_001007025.2 → NP_001007026.1  Golgi SNAP receptor complex member 1 isoform 2

    See identical proteins and their annotated locations for NP_001007026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame small segment of 6 nts in the 5' coding region, as compared to variant 1. The encoded isoform 2 thus lacks internal 2 aa, as compared to isoform 1.
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, BE785872, CB054624
    Consensus CDS
    CCDS45643.1
    UniProtKB/TrEMBL
    A8K5R6, E9PCW1
    Related
    ENSP00000414441.2, ENST00000451249.7
    Conserved Domains (1) summary
    cd15864
    Location:158 → 223
    SNARE_GS28; SNARE motif of GS28

  3. NM_004871.3 → NP_004862.1  Golgi SNAP receptor complex member 1 isoform 1

    See identical proteins and their annotated locations for NP_004862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011840, AK000606, AK074298, BC040072, BC040471, CB054624
    Consensus CDS
    CCDS11258.1
    UniProtKB/Swiss-Prot
    J3KST5, O75392, O95249
    UniProtKB/TrEMBL
    A8K5R6
    Related
    ENSP00000225724.5, ENST00000225724.9
    Conserved Domains (1) summary
    cd15864
    Location:160 → 225
    SNARE_GS28; SNARE motif of GS28

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    30477408..30527592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258070.6 → XP_005258127.1  Golgi SNAP receptor complex member 1 isoform X1

    UniProtKB/TrEMBL
    A8K5R6
    Conserved Domains (1) summary
    cd15864
    Location:210 → 275
    SNARE_GS28; SNARE motif of GS28

  2. XM_017025374.3 → XP_016880863.1  Golgi SNAP receptor complex member 1 isoform X3

    UniProtKB/TrEMBL
    A8K5R6

  3. XM_005258071.6 → XP_005258128.1  Golgi SNAP receptor complex member 1 isoform X2

    UniProtKB/TrEMBL
    A8K5R6
    Conserved Domains (1) summary
    cd15864
    Location:208 → 273
    SNARE_GS28; SNARE motif of GS28

  4. XM_047437109.1 → XP_047293065.1  Golgi SNAP receptor complex member 1 isoform X4

  5. XM_047437111.1 → XP_047293067.1  Golgi SNAP receptor complex member 1 isoform X7

  6. XM_047437110.1 → XP_047293066.1  Golgi SNAP receptor complex member 1 isoform X7

  7. XM_005258072.4 → XP_005258129.1  Golgi SNAP receptor complex member 1 isoform X7

    See identical proteins and their annotated locations for XP_005258129.1

    UniProtKB/Swiss-Prot
    O95249
    Conserved Domains (1) summary
    cd15864
    Location:95 → 160
    SNARE_GS28; SNARE motif of GS28

  8. XM_017025375.3 → XP_016880864.1  Golgi SNAP receptor complex member 1 isoform X5

    UniProtKB/TrEMBL
    K7EJC8
    Related
    ENSP00000465115.1, ENST00000581721.5

  9. XM_017025376.3 → XP_016880865.1  Golgi SNAP receptor complex member 1 isoform X6

    UniProtKB/TrEMBL
    K7EJC8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    31422038..31472230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317886.1 → XP_054173861.1  Golgi SNAP receptor complex member 1 isoform X7

  2. XM_054317883.1 → XP_054173858.1  Golgi SNAP receptor complex member 1 isoform X5

  3. XM_054317884.1 → XP_054173859.1  Golgi SNAP receptor complex member 1 isoform X6

  4. XM_054317879.1 → XP_054173854.1  Golgi SNAP receptor complex member 1 isoform X1

  5. XM_054317880.1 → XP_054173855.1  Golgi SNAP receptor complex member 1 isoform X2

  6. XM_054317881.1 → XP_054173856.1  Golgi SNAP receptor complex member 1 isoform X3

  7. XM_054317887.1 → XP_054173862.1  Golgi SNAP receptor complex member 1 isoform X7

  8. XM_054317885.1 → XP_054173860.1  Golgi SNAP receptor complex member 1 isoform X7

  9. XM_054317882.1 → XP_054173857.1  Golgi SNAP receptor complex member 1 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95249.1 GenPept UniProtKB/Swiss-Prot:O95249

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