U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem40 transmembrane protein 40 [ Mus musculus (house mouse) ]

Gene ID: 94346, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tmem40provided by MGI
Official Full Name
transmembrane protein 40provided by MGI
Primary source
MGI:MGI:2137870
See related
Ensembl:ENSMUSG00000059900 AllianceGenome:MGI:2137870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030407H20Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in lens; lens vesicle; and liver lobe. Orthologous to human TMEM40 (transmembrane protein 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 8.7), stomach adult (RPKM 6.9) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 E3; 6 53.68 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115706092..115739427, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115729131..115762466, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38879 Neighboring gene STARR-positive B cell enhancer ABC_E10402 Neighboring gene predicted gene, 24008 Neighboring gene STARR-seq mESC enhancer starr_17094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115724212-115724399 Neighboring gene predicted gene, 44180 Neighboring gene microRNA 7660 Neighboring gene cullin associated and neddylation dissociated 2 (putative)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Thut CJ, et al. Dev Biol, 2001 Mar 1. PMID 11180952
  2. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 40

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168256.1 → NP_001161728.1  transmembrane protein 40 isoform a

    See identical proteins and their annotated locations for NP_001161728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC109169, BY279100, CV561368, CX564997
    Consensus CDS
    CCDS39601.1
    UniProtKB/Swiss-Prot
    Q4FJU9, Q8C5D2, Q8VCR5
    UniProtKB/TrEMBL
    E9QN39
    Related
    ENSMUSP00000131697.2, ENSMUST00000166254.7
    Conserved Domains (1) summary
    pfam15817
    Location:105 → 224
    TMEM40; Transmembrane protein 40 family

  2. NM_001168257.1 → NP_001161729.1  transmembrane protein 40 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC109169, BY279100, CV561368
    Consensus CDS
    CCDS51879.1
    UniProtKB/TrEMBL
    E9Q6I9
    Related
    ENSMUSP00000130407.2, ENSMUST00000170625.8
    Conserved Domains (1) summary
    pfam15817
    Location:80 → 199
    TMEM40; Transmembrane protein 40 family

  3. NM_144805.2 → NP_659054.2  transmembrane protein 40 isoform a

    See identical proteins and their annotated locations for NP_659054.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC109169, BY104106, BY767648, CV561368, CX564997
    Consensus CDS
    CCDS39601.1
    UniProtKB/Swiss-Prot
    Q4FJU9, Q8C5D2, Q8VCR5
    UniProtKB/TrEMBL
    E9QN39
    Related
    ENSMUSP00000072704.7, ENSMUST00000072933.13
    Conserved Domains (1) summary
    pfam15817
    Location:105 → 224
    TMEM40; Transmembrane protein 40 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115706092..115739427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152415.1 → XP_036008308.1  transmembrane protein 40 isoform X5

    Conserved Domains (1) summary
    pfam15817
    Location:36 → 155
    TMEM40; Transmembrane protein 40 family

  2. XM_036152416.1 → XP_036008309.1  transmembrane protein 40 isoform X5

    Conserved Domains (1) summary
    pfam15817
    Location:36 → 155
    TMEM40; Transmembrane protein 40 family

  3. XM_006506819.5 → XP_006506882.1  transmembrane protein 40 isoform X2

    See identical proteins and their annotated locations for XP_006506882.1

    UniProtKB/Swiss-Prot
    Q4FJU9, Q8C5D2, Q8VCR5
    UniProtKB/TrEMBL
    E9QN39
    Conserved Domains (1) summary
    pfam15817
    Location:105 → 224
    TMEM40; Transmembrane protein 40 family

  4. XM_011241511.3 → XP_011239813.1  transmembrane protein 40 isoform X2

    See identical proteins and their annotated locations for XP_011239813.1

    UniProtKB/Swiss-Prot
    Q4FJU9, Q8C5D2, Q8VCR5
    UniProtKB/TrEMBL
    E9QN39
    Conserved Domains (1) summary
    pfam15817
    Location:105 → 224
    TMEM40; Transmembrane protein 40 family

  5. XM_011241510.3 → XP_011239812.1  transmembrane protein 40 isoform X1

    UniProtKB/TrEMBL
    E9QN39
    Conserved Domains (1) summary
    pfam15817
    Location:121 → 240
    TMEM40; Transmembrane protein 40 family

  6. XM_011241512.4 → XP_011239814.1  transmembrane protein 40 isoform X3

    UniProtKB/TrEMBL
    E9QN39
    Conserved Domains (1) summary
    pfam15817
    Location:102 → 221
    TMEM40; Transmembrane protein 40 family

  7. XM_011241513.4 → XP_011239815.1  transmembrane protein 40 isoform X4

    Conserved Domains (1) summary
    pfam15817
    Location:77 → 196
    TMEM40; Transmembrane protein 40 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001168258.1: Suppressed sequence

    Description
    NM_001168258.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  2. NM_001168259.1: Suppressed sequence

    Description
    NM_001168259.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FJU9.1 GenPept UniProtKB/Swiss-Prot:Q4FJU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous