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Sfxn4 sideroflexin 4 [ Mus musculus (house mouse) ]

Gene ID: 94281, updated on 11-Apr-2024

Summary

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Official Symbol
Sfxn4provided by MGI
Official Full Name
sideroflexin 4provided by MGI
Primary source
MGI:MGI:2137680
See related
Ensembl:ENSMUSG00000063698 AllianceGenome:MGI:2137680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial transmembrane transport. Predicted to act upstream of or within amino acid transport. Located in mitochondrion. Is expressed in brain; metanephros; and testis. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 18. Orthologous to human SFXN4 (sideroflexin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 2.7), cerebellum adult (RPKM 2.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D3; 19 56.52 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60824747..60850222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60836309..60861533, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene microRNA 3084-2 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene eukaryotic translation initiation factor 3, subunit A Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene STARR-positive B cell enhancer ABC_E11681 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965501-60965802 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965940-60966241 Neighboring gene peroxiredoxin 3 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. Fleming MD, et al. Genes Dev, 2001 Mar 15. PMID 11274051, Free PMC Article
  2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107253

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sideroflexin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362384.1 → NP_001349313.1  sideroflexin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102432, AC163019
    Conserved Domains (1) summary
    cl04275
    Location:1 → 217
    Mtc; Tricarboxylate carrier

  2. NM_001362385.1 → NP_001349314.1  sideroflexin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102432, AC163019, AK148530
    Conserved Domains (1) summary
    cl04275
    Location:1 → 212
    Mtc; Tricarboxylate carrier

  3. NM_053198.4 → NP_444428.3  sideroflexin-4 isoform 1

    See identical proteins and their annotated locations for NP_444428.3

    Status: VALIDATED

    Source sequence(s)
    AC102432, AC163019
    Consensus CDS
    CCDS29943.1
    UniProtKB/Swiss-Prot
    E9QKN7, Q5FW99, Q925N1
    Related
    ENSMUSP00000118743.2, ENSMUST00000135808.8
    Conserved Domains (1) summary
    pfam03820
    Location:15 → 312
    Mtc; Tricarboxylate carrier

RNA

  1. NR_189655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102432, AC163019

  2. NR_189656.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102432, AC163019

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60824747..60850222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161735.1 → XP_036017628.1  sideroflexin-4 isoform X1

    Conserved Domains (1) summary
    cl04275
    Location:15 → 287
    Mtc; Tricarboxylate carrier

  2. XM_030251146.2 → XP_030107006.1  sideroflexin-4 isoform X2

    Conserved Domains (1) summary
    cl04275
    Location:1 → 217
    Mtc; Tricarboxylate carrier

RNA

  1. XR_001782624.3 RNA Sequence

  2. XR_004940190.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925N1.2 GenPept UniProtKB/Swiss-Prot:Q925N1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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