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Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 [ Mus musculus (house mouse) ]

Gene ID: 94249, updated on 30-Apr-2024

Summary

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Official Symbol
Slc24a3provided by MGI
Official Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3provided by MGI
Primary source
MGI:MGI:2137513
See related
Ensembl:ENSMUSG00000063873 AllianceGenome:MGI:2137513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NCKX3
Summary
Enables calcium, potassium:sodium antiporter activity. Acts upstream of or within bone mineralization; cellular calcium ion homeostasis; and regulation of gene expression. Located in cell periphery. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; musculature; and neural retina. Orthologous to human SLC24A3 (solute carrier family 24 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 24.5), subcutaneous fat pad adult (RPKM 18.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.08 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145009695..145484086)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145167775..145642166)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05920 Neighboring gene predicted gene, 39952 Neighboring gene SCP2 sterol-binding domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_05921 Neighboring gene STARR-seq mESC enhancer starr_05922 Neighboring gene STARR-seq mESC enhancer starr_05923 Neighboring gene predicted gene, 52529 Neighboring gene predicted gene, 52528 Neighboring gene STARR-seq mESC enhancer starr_05924 Neighboring gene STARR-seq mESC enhancer starr_05925 Neighboring gene STARR-seq mESC enhancer starr_05926 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene STARR-seq mESC enhancer starr_05927 Neighboring gene predicted gene 14092 Neighboring gene a disintegrin and metallopeptidase domain 25 (testase 2) pseudogene Neighboring gene predicted gene, 52530 Neighboring gene cDNA sequence BC039771 Neighboring gene predicted gene, 54120 Neighboring gene predicted gene, 34513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice. Tran DN, et al. J Physiol Pharmacol, 2020 Aug. PMID 33214341
  2. Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-κB Pathway. Tran DN, et al. Int J Mol Sci, 2021 Mar 5. PMID 33807999, Free PMC Article
  3. NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model. Yang H, et al. Mol Cell Endocrinol, 2017 Oct 15. PMID 28602864
  4. K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney. Lee GS, et al. Am J Physiol Renal Physiol, 2009 Aug. PMID 19474185
  5. Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle. Yang H, et al. Biochem Biophys Res Commun, 2009 Jul 24. PMID 19464262

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice.
    Title: Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice.
  2. Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway.
    Title: Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-κB Pathway.
  3. NCKX3 may play a role in regulating calcium homeostasis.
    Title: NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model.
  4. Suggest that a high level of renal NCKX3 expression maintain in distal convoluted tubules may play a role in active calcium transport in the kidneys of female mice.
    Title: K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney.
  5. The results of the present study indicate that NCKX3 is abundantly expressed in the uterus and that its expression is regulated by the steroid hormones E2 and P4.
    Title: Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium, potassium:sodium antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium, potassium:sodium antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium, potassium:sodium antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium, potassium:sodium antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis TAS
Traceable Author Statement
more info
 PubMed 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium/calcium exchanger 3
Names
Na(+)/K(+)/Ca(2+)-exchange protein 3
solute carrier family 24 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356497.1 → NP_001343426.1  sodium/potassium/calcium exchanger 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL772192, AL808117, AL824715, AL831783
    Consensus CDS
    CCDS89560.1
    UniProtKB/Swiss-Prot
    B1AWL7, Q99JR2, Q99PD7, Q99PD8
    Related
    ENSMUSP00000105634.2, ENSMUST00000110007.8
    Conserved Domains (1) summary
    cl27511
    Location:89 → 631
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_053195.3 → NP_444425.1  sodium/potassium/calcium exchanger 3 isoform 2

    See identical proteins and their annotated locations for NP_444425.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL808117, AL824715, AL831783
    Consensus CDS
    CCDS38256.1
    UniProtKB/TrEMBL
    Q8VD29
    Related
    ENSMUSP00000079897.4, ENSMUST00000081121.4
    Conserved Domains (2) summary
    TIGR00367
    Location:61 → 557
    TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
    pfam01699
    Location:62 → 204
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145009695..145484086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PD7.3 GenPept UniProtKB/Swiss-Prot:Q99PD7

Gene LinkOut

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