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Pi15 peptidase inhibitor 15 [ Mus musculus (house mouse) ]

Gene ID: 94227, updated on 3-Apr-2024

Summary

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Official Symbol
Pi15provided by MGI
Official Full Name
peptidase inhibitor 15provided by MGI
Primary source
MGI:MGI:1934659
See related
Ensembl:ENSMUSG00000067780 AllianceGenome:MGI:1934659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P24TI; P25TI; PI-15; SugarCrisp
Summary
Predicted to enable peptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in glomerular tuft; renal cortex; s-shaped body; visceral epithelium of capillary loop renal corpuscle; and visceral epithelium of mature renal corpuscle. Orthologous to human PI15 (peptidase inhibitor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1.8), genital fat pad adult (RPKM 1.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A3; 1 5.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (17672064..17701169)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (17601901..17630939)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00359 Neighboring gene peptidylprolyl isomerase A pseudogene 1_125.1 Neighboring gene STARR-seq mESC enhancer starr_00360 Neighboring gene STARR-seq mESC enhancer starr_00361 Neighboring gene STARR-seq mESC enhancer starr_00362 Neighboring gene STARR-seq mESC enhancer starr_00364 Neighboring gene predicted gene, 25166 Neighboring gene predicted gene 28154 Neighboring gene STARR-seq mESC enhancer starr_00366 Neighboring gene predicted gene 16070 Neighboring gene cysteine-rich secretory protein LCCL domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_00368 Neighboring gene high mobility group box transcription factor 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo. Smith DM, et al. Mech Dev, 2001 Apr. PMID 11287197
  2. Large-scale identification of genes implicated in kidney glomerulus development and function. Takemoto M, et al. EMBO J, 2006 Mar 8. PMID 16498405, Free PMC Article
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidase inhibitor 15
Names
cysteine-rich secreted protein
protease inhibitor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053191.5 → NP_444421.3  peptidase inhibitor 15 precursor

    Status: VALIDATED

    Source sequence(s)
    AC104917
    Consensus CDS
    CCDS48225.1
    UniProtKB/Swiss-Prot
    Q3TN14, Q8BS03, Q99MM7
    Related
    ENSMUSP00000085826.3, ENSMUST00000088476.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    17672064..17701169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154509.1 → XP_036010402.1  peptidase inhibitor 15 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J126
    Conserved Domains (1) summary
    cd18814
    Location:78 → 223
    CAP_PI15; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BS03.2 GenPept UniProtKB/Swiss-Prot:Q8BS03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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