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Dgcr8 DGCR8, microprocessor complex subunit [ Mus musculus (house mouse) ]

Gene ID: 94223, updated on 21-Apr-2024

Summary

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Official Symbol
Dgcr8provided by MGI
Official Full Name
DGCR8, microprocessor complex subunitprovided by MGI
Primary source
MGI:MGI:2151114
See related
Ensembl:ENSMUSG00000022718 AllianceGenome:MGI:2151114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gy1; N41; D16Wis2; Vo59c07; mir-1306; D16H22S788E; D16H22S1742E
Summary
Enables primary miRNA binding activity. Acts upstream of or within regulation of stem cell proliferation. Located in postsynaptic density. Is expressed in several structures, including brain; branchial arch; cardiovascular system; facial prominence; and hemolymphoid system. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 9.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 A3; 16 11.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18071812..18107115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18253948..18289251, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18231149-18231350 Neighboring gene zinc finger, DHHC domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E8621 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene STARR-positive B cell enhancer ABC_E1921 Neighboring gene microRNA 1306 Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene STARR-positive B cell enhancer ABC_E10891 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene catechol-O-methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response. Daum P, et al. Front Immunol, 2022. PMID 36591274, Free PMC Article
  2. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes. Vardapour R, et al. Carcinogenesis, 2022 Mar 24. PMID 34919667
  3. Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits. Zick JL, et al. Curr Biol, 2022 Jan 10. PMID 34678162, Free PMC Article
  4. Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation. Zou Y, et al. Sci Rep, 2018 Jan 23. PMID 29362439, Free PMC Article
  5. The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells. Gambardella G, et al. Nat Commun, 2017 Jan 19. PMID 28102192, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
    Title: Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
  2. RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
    Title: RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
  3. Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
    Title: Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
  4. The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
    Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
  5. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
    Title: The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
  6. Global miRNA dosage control of embryonic germ layer specification.
    Title: Global miRNA dosage control of embryonic germ layer specification.
  7. DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
    Title: DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
  8. Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
    Title: Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
  9. DGCR8 overexpression alleviated hMSC aging and mouse osteoarthritis.
    Title: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.
  10. The Ddx6 knockout cells were phenotypically and molecularly similar to cells lacking all microRNAs (Dgcr8 knockout ESCs). These data show that the loss of DDX6 can separate the two canonical functions of microRNAs: translational repression and transcript destabilization
    Title: Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables primary miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables primary miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of microprocessor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
microprocessor complex subunit DGCR8
Names
DiGeorge syndrome critical region gene 8
diGeorge syndrome critical region 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033324.2 → NP_201581.2  microprocessor complex subunit DGCR8

    See identical proteins and their annotated locations for NP_201581.2

    Status: VALIDATED

    Source sequence(s)
    AB086857
    Consensus CDS
    CCDS28018.1
    UniProtKB/Swiss-Prot
    Q9EQM6
    Related
    ENSMUSP00000009321.5, ENSMUST00000009321.11
    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:618 → 686
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18071812..18107115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522795.3 → XP_006522858.1  microprocessor complex subunit DGCR8 isoform X1

    See identical proteins and their annotated locations for XP_006522858.1

    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:639 → 707
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

  2. XM_030249355.2 → XP_030105215.1  microprocessor complex subunit DGCR8 isoform X2

    UniProtKB/Swiss-Prot
    Q9EQM6
    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:618 → 686
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

  3. XM_030249354.2 → XP_030105214.1  microprocessor complex subunit DGCR8 isoform X1

    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:639 → 707
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

  4. XM_030249352.1 → XP_030105212.1  microprocessor complex subunit DGCR8 isoform X1

    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:639 → 707
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

  5. XM_030249353.1 → XP_030105213.1  microprocessor complex subunit DGCR8 isoform X1

    Conserved Domains (3) summary
    smart00456
    Location:302 → 332
    WW; Domain with 2 conserved Trp (W) residues
    cd19867
    Location:505 → 578
    DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
    cd19868
    Location:639 → 707
    DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQM6.2 GenPept UniProtKB/Swiss-Prot:Q9EQM6

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