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Adarb2 adenosine deaminase, RNA-specific, B2 [ Mus musculus (house mouse) ]

Gene ID: 94191, updated on 21-Apr-2024

Summary

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Official Symbol
Adarb2provided by MGI
Official Full Name
adenosine deaminase, RNA-specific, B2provided by MGI
Primary source
MGI:MGI:2151118
See related
Ensembl:ENSMUSG00000052551 AllianceGenome:MGI:2151118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RED2; Adar3
Summary
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; integumental system; limb; and sensory organ. Orthologous to human ADARB2 (adenosine deaminase RNA specific B2 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 3.3), CNS E18 (RPKM 2.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A1; 13 3.48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (8252475..8818798)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (8202526..8768762)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33590 Neighboring gene STARR-seq mESC enhancer starr_33591 Neighboring gene polo-like kinase 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33592 Neighboring gene STARR-seq mESC enhancer starr_33593 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33594 Neighboring gene STARR-seq mESC enhancer starr_33595 Neighboring gene STARR-seq mESC enhancer starr_33596 Neighboring gene STARR-seq mESC enhancer starr_33598 Neighboring gene STARR-positive B cell enhancer ABC_E8888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:8870257-8870604 Neighboring gene WD repeat domain 37 Neighboring gene isopentenyl-diphosphate delta isomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice. Li Z, et al. Gene, 2021 Dec 30. PMID 34419568
  2. Adar3 Is Involved in Learning and Memory in Mice. Mladenova D, et al. Front Neurosci, 2018. PMID 29719497, Free PMC Article
  3. Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish. Slavov D, et al. Gene, 2000 May 30. PMID 10854777
  4. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nicod J, et al. Nat Genet, 2016 Aug. PMID 27376238, Free PMC Article
  5. Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos. García-López J, et al. Nucleic Acids Res, 2013 May 1. PMID 23571754, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice.
    Title: ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by targeting NLRP3 in chronic constriction injury mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
double-stranded RNA-specific editase B2
Names
RNA dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
adenosine deaminase 3, RNA dependent
dsRNA adenosine deaminase B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289530.1 → NP_001276459.1  double-stranded RNA-specific editase B2 isoform 2

    See identical proteins and their annotated locations for NP_001276459.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a frameshift and a protein (isoform 2) with a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK046083, AK134964
    Consensus CDS
    CCDS70428.1
    UniProtKB/TrEMBL
    Q6PB89, Q8BQZ3
    Related
    ENSMUSP00000120757.2, ENSMUST00000123187.2
    Conserved Domains (2) summary
    smart00552
    Location:366 → 687
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:125 → 189
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  2. NM_052977.5 → NP_443209.2  double-stranded RNA-specific editase B2 isoform 1

    See identical proteins and their annotated locations for NP_443209.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK134964, AK139079
    Consensus CDS
    CCDS26231.1
    UniProtKB/Swiss-Prot
    Q3UTP1, Q8CC51, Q9JI20, Q9JIE5
    UniProtKB/TrEMBL
    Q3UY54
    Related
    ENSMUSP00000064775.7, ENSMUST00000064473.13
    Conserved Domains (3) summary
    smart00358
    Location:284 → 331
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:366 → 742
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:125 → 189
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RNA

  1. NR_110345.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and has a novel 3' terminus, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK134964, AV327940, BC059822

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    8252475..8818798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315647.3 → XP_017171136.1  double-stranded RNA-specific editase B2 isoform X1

    UniProtKB/TrEMBL
    Q3UY54
    Conserved Domains (3) summary
    smart00552
    Location:366 → 739
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19896
    Location:122 → 195
    DSRM_RED2_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins
    cl00054
    Location:276 → 349
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

RNA

  1. XR_382016.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JI20.2 GenPept UniProtKB/Swiss-Prot:Q9JI20

Gene LinkOut

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