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Zfp423 zinc finger protein 423 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94188, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp423provided by RGD
Official Full Name
zinc finger protein 423provided by RGD
Primary source
RGD:621664
See related
Ensembl:ENSRNOG00000014658 AllianceGenome:RGD:621664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Roaz; Znf423
Summary
Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 52.6), Brain (RPKM 50.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (35282149..35580775)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (19111213..19407373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (20147201..20405999)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348906 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 7 Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC134483302 Neighboring gene uncharacterized LOC134483301 Neighboring gene uncharacterized LOC120098541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Tsai RY, et al. Mol Cell Biol, 1998 Nov. PMID 9774661, Free PMC Article
  2. Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Shao M, et al. Cell Metab, 2016 Jun 14. PMID 27238639, Free PMC Article
  3. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Hata A, et al. Cell, 2000 Jan 21. PMID 10660046
  4. Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. Tsai RY, et al. J Neurosci, 1997 Jun 1. PMID 9151733, Free PMC Article
  5. ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. Masserdotti G, et al. J Biol Chem, 2010 Oct 1. PMID 20547764, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellar granule cell precursor proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to cilium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein 423
Names
Olf-1/EBF associated Zn finger protein Roaz
olf1/EBF-associated zinc finger protein
smad- and Olf-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393718.1 → NP_001380647.1  zinc finger protein 423

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    O08961, Q63681
    UniProtKB/TrEMBL
    A0A8I5ZY81
    Related
    ENSRNOP00000082983.1, ENSRNOT00000101491.1
    Conserved Domains (2) summary
    COG5048
    Location:202 → 603
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    35282149..35580775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278334.1 → XP_063134404.1  zinc finger protein 423 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A1R1, A6KDA7

  2. XM_063278328.1 → XP_063134398.1  zinc finger protein 423 isoform X1

  3. XM_063278329.1 → XP_063134399.1  zinc finger protein 423 isoform X2

  4. XM_063278333.1 → XP_063134403.1  zinc finger protein 423 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A1R1, A6KDA7

  5. XM_063278330.1 → XP_063134400.1  zinc finger protein 423 isoform X2

  6. XM_063278332.1 → XP_063134402.1  zinc finger protein 423 isoform X2

  7. XM_063278331.1 → XP_063134401.1  zinc finger protein 423 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053583.2: Suppressed sequence

    Description
    NM_053583.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08961.2 GenPept UniProtKB/Swiss-Prot:O08961

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