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Prdx6 peroxiredoxin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94167, updated on 11-Apr-2024

Summary

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Official Symbol
Prdx6provided by RGD
Official Full Name
peroxiredoxin 6provided by RGD
Primary source
RGD:71005
See related
AllianceGenome:RGD:71005
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LPCAT-5
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity and glutathione peroxidase activity. Involved in hydrogen peroxide catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol and mitochondrion. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 1481.6), Heart (RPKM 904.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prdx6 in Genome Data Viewer
Location:
13q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (76062082..76072631, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73528746..73539295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79077567..79088113, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene solute carrier family 9, member C2 (putative) Neighboring gene uncharacterized LOC102552207 Neighboring gene actin, gamma 1, pseudogene 4 Neighboring gene glutaminyl-tRNA amidotransferase subunit QRSL1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy. Hong T, et al. Neuroscience, 2022 Feb 1. PMID 34863856
  2. Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway. Tang B, et al. Tissue Cell, 2021 Dec. PMID 34482185
  3. Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells. Novoselova EG, et al. Biochemistry (Mosc), 2019 Jun. PMID 31238863
  4. [Knockdown of PRDX6 in microglia reduces neuron viability after OGD/R injury]. Tan L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016 Aug. PMID 27412928
  5. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against ionizing radiation. Zhang S, et al. Free Radic Biol Med, 2014 Apr. PMID 24447893

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha Activation in Rats Fed High-Fat Diet.
    Title: PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet.
  2. PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.
    Title: PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.
  3. Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.
    Title: Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.
  4. Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway.
    Title: Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway.
  5. Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury.
    Title: Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury.
  6. The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence(s).
    Title: The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence(s).
  7. regulation of the NF-kappaB signaling cascade could be one of the mechanisms of Prx6 action on beta-cells, in particular, through activation of RelA/p65 phosphorylation at Ser536
    Title: Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells.
  8. Prdx6 upregulation by Cur treatment attenuates ischemic oxidative damage through SP1 induction in rats after stroke. This represents a novel mechanism of Cur-induced neuroprotection against cerebral ischemia.
    Title: Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.
  9. Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis induced by silica.
    Title: Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
  10. Data suggest the peroxiredoxin 6 (PRDX6) in microglia protects neuron against oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury.
    Title: [Knockdown of PRDX6 in microglia reduces neuron viability after OGD/R injury].
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bleb assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxiredoxin-6
Names
1-Cys PRX
1-Cys peroxiredoxin
LPC acyltransferase 5
NSGPx
acidic calcium-independent phospholipase A2
aiPLA2
antioxidant protein 2
glutathione-dependent peroxiredoxin
lyso-PC acyltransferase 5
lysophosphatidylcholine acyltransferase 5
non-selenium glutathione peroxidase
thiol-specific antioxidant protein
NP_446028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053576.2 → NP_446028.1  peroxiredoxin-6

    See identical proteins and their annotated locations for NP_446028.1

    Status: PROVISIONAL

    Source sequence(s)
    AF014009
    UniProtKB/Swiss-Prot
    O35244
    UniProtKB/TrEMBL
    A0A8I5ZYW1, A6ID81
    Conserved Domains (1) summary
    cd03016
    Location:7 → 222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    76062082..76072631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35244.3 GenPept UniProtKB/Swiss-Prot:O35244

Gene LinkOut

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