U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trim34a tripartite motif-containing 34A [ Mus musculus (house mouse) ]

Gene ID: 94094, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Trim34aprovided by MGI
Official Full Name
tripartite motif-containing 34Aprovided by MGI
Primary source
MGI:MGI:2137359
See related
Ensembl:ENSMUSG00000056144 AllianceGenome:MGI:2137359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trim34; Trim34-1
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and regulation of viral entry into host cell. Predicted to act upstream of or within defense response to virus. Predicted to be active in cytosol and nucleoplasm. Is expressed in testis and ureter. Orthologous to several human genes including TRIM34 (tripartite motif containing 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 7.3), spleen adult (RPKM 7.0) and 28 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 E3; 7 55.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103893657..103911446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104244448..104262244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 6, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_19731 Neighboring gene tripartite motif-containing 6 Neighboring gene predicted gene 8667 Neighboring gene STARR-positive B cell enhancer ABC_E6578 Neighboring gene STARR-seq mESC enhancer starr_19732 Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5 Neighboring gene predicted gene, 57517

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. Wang X, et al. J Biol Chem, 2022 Mar. PMID 35065966, Free PMC Article
  2. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
  3. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
  4. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase TRIM34A
Names
tripartite motif protein 34
tripartite motif-containing 34
tripartite motif-containing protein 34
tripartite motif-containing protein 34A
NP_001344608.1
NP_001408613.1
NP_109609.2
XP_006508432.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357679.2 → NP_001344608.1  E3 ubiquitin-protein ligase TRIM34A

    Status: VALIDATED

    Source sequence(s)
    AC123830
    Consensus CDS
    CCDS52342.1
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Related
    ENSMUSP00000055058.6, ENSMUST00000060315.12
    Conserved Domains (4) summary
    TIGR02168
    Location:134 → 241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299 → 482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:14 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001421684.1 → NP_001408613.1  E3 ubiquitin-protein ligase TRIM34A

    Status: VALIDATED

    Source sequence(s)
    AC123830
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6

  3. NM_030684.4 → NP_109609.2  E3 ubiquitin-protein ligase TRIM34A

    See identical proteins and their annotated locations for NP_109609.2

    Status: VALIDATED

    Source sequence(s)
    AC123830
    Consensus CDS
    CCDS52342.1
    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Related
    ENSMUSP00000102462.3, ENSMUST00000106849.9
    Conserved Domains (4) summary
    TIGR02168
    Location:134 → 241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299 → 482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:14 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_185321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123830

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103893657..103911446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508369.4 → XP_006508432.1  E3 ubiquitin-protein ligase TRIM34A isoform X1

    See identical proteins and their annotated locations for XP_006508432.1

    UniProtKB/Swiss-Prot
    E9PYZ4, F8VPK2, Q99PP4, Q99PP5, Q99PP6
    UniProtKB/TrEMBL
    Q3TAH7
    Conserved Domains (4) summary
    TIGR02168
    Location:134 → 241
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd15825
    Location:299 → 482
    SPRY_PRY_TRIM34; PRY/SPRY domain in tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein (IFP1)
    cd19761
    Location:94 → 133
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
    cl17238
    Location:14 → 60
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_003946603.2 RNA Sequence

  2. XR_004934226.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PP6.3 GenPept UniProtKB/Swiss-Prot:Q99PP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous