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Trim7 tripartite motif-containing 7 [ Mus musculus (house mouse) ]

Gene ID: 94089, updated on 21-Apr-2024

Summary

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Official Symbol
Trim7provided by MGI
Official Full Name
tripartite motif-containing 7provided by MGI
Primary source
MGI:MGI:2137353
See related
Ensembl:ENSMUSG00000040350 AllianceGenome:MGI:2137353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytoplasm and nucleus. Orthologous to human TRIM7 (tripartite motif containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 20.2), spleen adult (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.2; 11 28.8 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48716965..48742019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48826138..48851192)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1822 Neighboring gene nuclear encoded tRNA valine 7 (anticodon CAC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon ACC) Neighboring gene cyclin dependent kinase 2 associated protein 1 retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E3945 Neighboring gene nuclear encoded tRNA lysine 10 (anticodon CTT) Neighboring gene nuclear encoded tRNA alanine 9 (anticodon TGC) Neighboring gene predicted gene 16170 Neighboring gene STARR-positive B cell enhancer ABC_E5220 Neighboring gene nuclear encoded tRNA threonine 2 (anticodon TGT) Neighboring gene nuclear encoded tRNA proline 4 (anticodon TGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection. Wang J, et al. Autophagy, 2023 Jun. PMID 36576150, Free PMC Article
  2. Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS. Yang B, et al. Front Immunol, 2021. PMID 34512666, Free PMC Article
  3. RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation. Yang B, et al. PLoS Pathog, 2020 Mar. PMID 32126128, Free PMC Article
  4. E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages. Lu M, et al. Mol Immunol, 2019 May. PMID 30928727
  5. GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle. Montori-Grau M, et al. Metabolism, 2018 Jun. PMID 29466708

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
    Title: TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
  2. Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
    Title: Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
  3. findings suggested a novel function of RNF90 in innate immunity.
    Title: RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
  4. TRIM7 may facilitate the TLR4-mediated innate response via its E3 ligase domain in macrophages.
    Title: E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages.
  5. GNIP1 is an ubiquitin ligase with a markedly glycogenic effect in skeletal muscle.
    Title: GNIP1 E3 ubiquitin ligase is a novel player in regulating glycogen metabolism in skeletal muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM7
Names
glycogenin-interacting protein
tripartite motif protein 7
tripartite motif-containing protein 7
NP_001334375.1
NP_444396.2
XP_006534631.1
XP_006534632.1
XP_006534634.1
XP_006534636.1
XP_006534637.1
XP_006534638.1
XP_006534639.1
XP_006534640.1
XP_011247635.1
XP_017170349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347446.1 → NP_001334375.1  E3 ubiquitin-protein ligase TRIM7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AL645849
    Consensus CDS
    CCDS83797.1
    UniProtKB/Swiss-Prot
    Q5NCB6, Q923T7, Q99PQ5
    UniProtKB/TrEMBL
    Q5NCB7
    Related
    ENSMUSP00000039011.6, ENSMUST00000046903.6

  2. NM_053166.2 → NP_444396.2  E3 ubiquitin-protein ligase TRIM7 isoform 1

    See identical proteins and their annotated locations for NP_444396.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 1, which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AL645849
    Consensus CDS
    CCDS48779.1
    UniProtKB/Swiss-Prot
    Q923T7
    Related
    ENSMUSP00000104836.3, ENSMUST00000109213.9
    Conserved Domains (1) summary
    cd13740
    Location:137 → 303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48716965..48742019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534568.4 → XP_006534631.1  E3 ubiquitin-protein ligase TRIM7 isoform X1

    UniProtKB/Swiss-Prot
    Q5NCB6, Q923T7, Q99PQ5
    Conserved Domains (5) summary
    COG4942
    Location:255 → 357
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:426 → 592
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
    cd00162
    Location:29 → 80
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19762
    Location:129 → 170
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:26 → 81
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_006534569.4 → XP_006534632.1  E3 ubiquitin-protein ligase TRIM7 isoform X2

    UniProtKB/Swiss-Prot
    Q5NCB6, Q923T7, Q99PQ5
    Conserved Domains (5) summary
    COG4942
    Location:254 → 356
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:425 → 591
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)
    cd00162
    Location:29 → 80
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19762
    Location:129 → 170
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:26 → 81
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_011249333.3 → XP_011247635.1  E3 ubiquitin-protein ligase TRIM7 isoform X6

    UniProtKB/TrEMBL
    B2RR25
    Conserved Domains (4) summary
    cd00162
    Location:29 → 80
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd19762
    Location:129 → 170
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl17238
    Location:26 → 81
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl21478
    Location:158 → 204
    ATP-synt_B; ATP synthase B/B' CF(0)

  4. XM_006534573.5 → XP_006534636.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

    See identical proteins and their annotated locations for XP_006534636.1

    Conserved Domains (2) summary
    COG4942
    Location:33 → 135
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:204 → 370
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  5. XM_006534575.5 → XP_006534638.1  E3 ubiquitin-protein ligase TRIM7 isoform X5

    See identical proteins and their annotated locations for XP_006534638.1

    UniProtKB/Swiss-Prot
    Q923T7
    Conserved Domains (1) summary
    cd13740
    Location:137 → 303
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  6. XM_006534577.5 → XP_006534640.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

    See identical proteins and their annotated locations for XP_006534640.1

    Conserved Domains (2) summary
    COG4942
    Location:33 → 135
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:204 → 370
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  7. XM_006534576.4 → XP_006534639.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

    See identical proteins and their annotated locations for XP_006534639.1

    Conserved Domains (2) summary
    COG4942
    Location:33 → 135
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:204 → 370
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  8. XM_017314860.2 → XP_017170349.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

    Conserved Domains (2) summary
    COG4942
    Location:33 → 135
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:204 → 370
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  9. XM_006534571.4 → XP_006534634.1  E3 ubiquitin-protein ligase TRIM7 isoform X3

    Conserved Domains (2) summary
    COG4942
    Location:83 → 185
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:254 → 420
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

  10. XM_006534574.5 → XP_006534637.1  E3 ubiquitin-protein ligase TRIM7 isoform X4

    See identical proteins and their annotated locations for XP_006534637.1

    Conserved Domains (2) summary
    COG4942
    Location:33 → 135
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd13740
    Location:204 → 370
    SPRY_PRY_TRIM7; PRY/SPRY domain in tripartite motif-binding protein 7 (TRIM7)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001347436.1: Suppressed sequence

    Description
    NM_001347436.1: This RefSeq was removed because the transcript was partial at the 5'' end, resulting in a partial CDS.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923T7.2 GenPept UniProtKB/Swiss-Prot:Q923T7

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