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Trim6 tripartite motif-containing 6 [ Mus musculus (house mouse) ]

Gene ID: 94088, updated on 5-Mar-2024

Summary

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Official Symbol
Trim6provided by MGI
Official Full Name
tripartite motif-containing 6provided by MGI
Primary source
MGI:MGI:2137352
See related
Ensembl:ENSMUSG00000072244 AllianceGenome:MGI:2137352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Ertd684e; C430046K18Rik
Summary
Enables DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in testis. Orthologous to human TRIM6 (tripartite motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 14.8) and colon adult (RPKM 1.4) See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 55.55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103868002..103884359)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104218795..104235152)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily H member 2 Neighboring gene olfactory receptor family 52 subfamily B member 6, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_19731 Neighboring gene predicted gene 8667 Neighboring gene STARR-positive B cell enhancer ABC_E6578 Neighboring gene STARR-seq mESC enhancer starr_19732 Neighboring gene tripartite motif-containing 34A Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly. van Tol S, et al. PLoS Pathog, 2022 May. PMID 35533195, Free PMC Article
  2. E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis. Zeng G, et al. Aging (Albany NY), 2019 Jun 6. PMID 31171760, Free PMC Article
  3. TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer. Zhang Y, et al. Oxid Med Cell Longev, 2023. PMID 36654781, Free PMC Article
  4. TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. Sato T, et al. J Cell Sci, 2012 Mar 15. PMID 22328504
  5. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.
    Title: TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.
  2. TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
    Title: TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
  3. these results suggest that TRIM6 aggravates MI/R injury through promoting IKKepsilon/STAT1 activation-dependent cardiomyocyte apoptosis
    Title: E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.
  4. TRIM6 regulates the transcriptional activity of Myc during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc-mediated transcription in embryonic stem cells.
    Title: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in free ubiquitin chain polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 6
Names
RING-type E3 ubiquitin transferase TRIM6
tripartite motif protein 6
NP_001013637.1
XP_006508427.1
XP_006508428.1
XP_006508429.1
XP_017167896.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013616.2 → NP_001013637.1  tripartite motif-containing protein 6

    See identical proteins and their annotated locations for NP_001013637.1

    Status: VALIDATED

    Source sequence(s)
    AC123830, AK049238, BB634731
    Consensus CDS
    CCDS40065.1
    UniProtKB/Swiss-Prot
    B2RSQ8, Q8BGE7, Q99PQ6
    UniProtKB/TrEMBL
    A0A1L1SS93
    Related
    ENSMUSP00000095782.4, ENSMUST00000098180.10
    Conserved Domains (4) summary
    TIGR03319
    Location:145 → 238
    RNase_Y; ribonuclease Y
    cd15823
    Location:299 → 486
    SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
    cd16591
    Location:12 → 61
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cd19761
    Location:97 → 134
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103868002..103884359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312407.2 → XP_017167896.1  tripartite motif-containing protein 6 isoform X2

    Conserved Domains (3) summary
    TIGR03319
    Location:145 → 238
    RNase_Y; ribonuclease Y
    cd16591
    Location:12 → 61
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cd19761
    Location:97 → 134
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

  2. XM_006508365.4 → XP_006508428.1  tripartite motif-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006508428.1

    UniProtKB/Swiss-Prot
    B2RSQ8, Q8BGE7, Q99PQ6
    UniProtKB/TrEMBL
    A0A1L1SS93
    Conserved Domains (4) summary
    TIGR03319
    Location:145 → 238
    RNase_Y; ribonuclease Y
    cd15823
    Location:299 → 486
    SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
    cd16591
    Location:12 → 61
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cd19761
    Location:97 → 134
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

  3. XM_006508366.4 → XP_006508429.1  tripartite motif-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006508429.1

    UniProtKB/Swiss-Prot
    B2RSQ8, Q8BGE7, Q99PQ6
    UniProtKB/TrEMBL
    A0A1L1SS93
    Related
    ENSMUSP00000149805.2, ENSMUST00000214578.2
    Conserved Domains (4) summary
    TIGR03319
    Location:145 → 238
    RNase_Y; ribonuclease Y
    cd15823
    Location:299 → 486
    SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
    cd16591
    Location:12 → 61
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cd19761
    Location:97 → 134
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

  4. XM_006508364.3 → XP_006508427.1  tripartite motif-containing protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006508427.1

    UniProtKB/Swiss-Prot
    B2RSQ8, Q8BGE7, Q99PQ6
    UniProtKB/TrEMBL
    A0A1L1SS93
    Conserved Domains (4) summary
    TIGR03319
    Location:145 → 238
    RNase_Y; ribonuclease Y
    cd15823
    Location:299 → 486
    SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)
    cd16591
    Location:12 → 61
    RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins
    cd19761
    Location:97 → 134
    Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGE7.1 GenPept UniProtKB/Swiss-Prot:Q8BGE7

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