Clec2h C-type lectin domain family 2, member h [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec2hprovided by MGI
Official Full Name: C-type lectin domain family 2, member hprovided by MGI
Primary source: MGI:MGI:2136934
See related: Ensembl:ENSMUSG00000030364 AllianceGenome:MGI:2136934
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clrf; clr-f
Summary: Enables natural killer cell lectin-like receptor binding activity. Predicted to act upstream of or within cellular defense response. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC2D (C-type lectin domain family 2 member D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 112.0), small intestine adult (RPKM 47.7) and 4 other tissues See more
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Genomic context

Location:: 6 F3; 6 63.07 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128639348..128654337)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128662385..128677374)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clr-f expression regulates kidney immune and metabolic homeostasis.
Title: Clr-f expression regulates kidney immune and metabolic homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

D6Mit257 (e-PCR), detects polymorphism
- UniSTS:130806

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables natural killer cell lectin-like receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular defense response	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 2 member H

Names: C-type lectin-related protein F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053165.5 → NP_444395.2 C-type lectin domain family 2 member H

See identical proteins and their annotated locations for NP_444395.2

Status: VALIDATED

Source sequence(s)

AC132352, AK090364, BB583062

Consensus CDS

CCDS20576.1

UniProtKB/Swiss-Prot

Q78IZ7, Q8C1T8, Q924B2

UniProtKB/TrEMBL

F5BFG9

Related

ENSMUSP00000032518.5, ENSMUST00000032518.7

Conserved Domains (1) summary

cd03593
Location:90 → 202

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)