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ZNF101 zinc finger protein 101 [ Homo sapiens (human) ]

Gene ID: 94039, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF101provided by HGNC
Official Full Name
zinc finger protein 101provided by HGNC
Primary source
HGNC:HGNC:12881
See related
Ensembl:ENSG00000181896 MIM:603983; AllianceGenome:HGNC:12881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF12
Summary
Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]
Expression
Broad expression in lymph node (RPKM 7.9), appendix (RPKM 4.5) and 22 other tissues See more
Orthologs
all
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Genomic context

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See ZNF101 in Genome Data Viewer
Location:
19p13.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19668153..19683506)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19805664..19821015)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19778962..19794315)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19739417-19740339 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19753343-19754298 Neighboring gene GEM interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10453 Neighboring gene ATPase 13A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19772231-19772878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19773833-19774815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10455 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779337-19779903 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19779904-19780469 Neighboring gene zinc finger protein 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10457 Neighboring gene uncharacterized LOC101060187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19858409-19858910 Neighboring gene sorting nexin 18 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel Krüppel-Associated Box identified in a panel of mammalian zinc finger proteins. Looman C, et al. Mamm Genome, 2004 Jan. PMID 14727140
  2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. Dehal P, et al. Science, 2001 Jul 6. PMID 11441184
  3. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
  4. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Aulchenko YS, et al. Nat Genet, 2009 Jan. PMID 19060911, Free PMC Article
  5. Genome-wide association study of selenium concentrations. Cornelis MC, et al. Hum Mol Genet, 2015 Mar 1. PMID 25343990, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association study of selenium concentrations.
EBI GWAS Catalog
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149565, MGC149566, DKFZp570I0164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 101
Names
zinc finger protein 101 (Y2)
zinc finger protein 12
zinc finger protein HZF12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300949.2 → NP_001287878.1  zinc finger protein 101 isoform 2

    See identical proteins and their annotated locations for NP_001287878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC011458, AY149174, BM972114, DB264378
    Consensus CDS
    CCDS77271.1
    UniProtKB/Swiss-Prot
    Q8IZC7
    Conserved Domains (2) summary
    COG5048
    Location:56 → 237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_033204.4 → NP_149981.2  zinc finger protein 101 isoform 1

    See identical proteins and their annotated locations for NP_149981.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011458, AY149174, BM972114, CR999939
    Consensus CDS
    CCDS32971.1
    UniProtKB/Swiss-Prot
    C9JU83, Q0VDG9, Q8IZC7
    Related
    ENSP00000468049.1, ENST00000592502.2
    Conserved Domains (6) summary
    cd11674
    Location:149 → 209
    lambda-1; inner capsid protein lambda-1 or VP3
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:176 → 357
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:340 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:240 → 264
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    19668153..19683506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439723.1 → XP_047295679.1  zinc finger protein 101 isoform X2

    Related
    ENSP00000400952.2, ENST00000415784.6

  2. XM_047439722.1 → XP_047295678.1  zinc finger protein 101 isoform X1

  3. XM_024451785.2 → XP_024307553.1  zinc finger protein 101 isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:56 → 237
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19805664..19821015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322682.1 → XP_054178657.1  zinc finger protein 101 isoform X5

  2. XM_054322680.1 → XP_054178655.1  zinc finger protein 101 isoform X3

  3. XM_054322681.1 → XP_054178656.1  zinc finger protein 101 isoform X4

  4. XM_054322683.1 → XP_054178658.1  zinc finger protein 101 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZC7.1 GenPept UniProtKB/Swiss-Prot:Q8IZC7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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