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CGB7 chorionic gonadotropin subunit beta 7 [ Homo sapiens (human) ]

Gene ID: 94027, updated on 23-Nov-2023

Summary

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Official Symbol
CGB7provided by HGNC
Official Full Name
chorionic gonadotropin subunit beta 7provided by HGNC
Primary source
HGNC:HGNC:16451
See related
Ensembl:ENSG00000196337 MIM:608826; AllianceGenome:HGNC:16451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGB6; CG-beta-a
Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 5.5), skin (RPKM 1.3) and 1 other tissue See more
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Genomic context

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Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49054274..49057749, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52049059..52052533, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49557531..49561006, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 pseudogene Neighboring gene chorionic gonadotropin subunit beta 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49557355-49557905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49558580-49559433 Neighboring gene uncharacterized LOC124904739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49559434-49560286 Neighboring gene neurotrophin 4 Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49574847-49575348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49575349-49575848

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit. Biskup K, et al. Glycoconj J, 2020 Oct. PMID 32767150, Free PMC Article
  2. Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin. Mise T, et al. J Biol Chem, 1981 Jul 10. PMID 7240231
  3. Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit. Carlsen RB, et al. J Biol Chem, 1973 Oct 10. PMID 4795659
  4. The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene. Sohr S, et al. Cell Cycle, 2011 Nov 1. PMID 22032922, Free PMC Article
  5. Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone. Lunardi-Iskandar Y, et al. Nature, 1995 May 4. PMID 7723844

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.
    Title: N- and O-glycosylation patterns and functional testing of CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG) beta subunit.
  2. Expression of the CGB7 gene is upregulated upon p53 induction in human HFF, HCT116 and DLD1 cells as well as in cell preparations enriched in human primary first-trimester trophoblasts.
    Title: The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35403, FLJ43118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in female gamete generation TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
choriogonadotropin subunit beta 7
Names
chorionic gonadotropin beta 7 subunit
chorionic gonadotropin beta subunit 7
chorionic gonadotropin, beta polypeptide 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385261.1 → NP_001372190.1  choriogonadotropin subunit beta 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS33071.1
    UniProtKB/Swiss-Prot
    P0DN87
    UniProtKB/TrEMBL
    A0A0F7RPU2, A0A0F7RQF0
    Related
    ENSP00000507822.1, ENST00000684222.1
    Conserved Domains (1) summary
    smart00068
    Location:25 → 131
    GHB; Glycoprotein hormone beta chain homologues

  2. NM_033142.2 → NP_149133.1  choriogonadotropin subunit beta 7 precursor

    See identical proteins and their annotated locations for NP_149133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS33071.1
    UniProtKB/Swiss-Prot
    P0DN87
    UniProtKB/TrEMBL
    A0A0F7RPU2, A0A0F7RQF0
    Related
    ENSP00000469076.1, ENST00000596965.5
    Conserved Domains (1) summary
    smart00068
    Location:25 → 131
    GHB; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49054274..49057749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52049059..52052533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DN87.1 GenPept UniProtKB/Swiss-Prot:P0DN87

Gene LinkOut

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