Hemgn hemogen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hemgnprovided by MGI
Official Full Name: hemogenprovided by MGI
Primary source: MGI:MGI:2136910
See related: Ensembl:ENSMUSG00000028332 AllianceGenome:MGI:2136910
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hgn; EDAG; mNDR; 4921524M03Rik
Summary: Predicted to be involved in regulation of osteoblast differentiation. Located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver. Orthologous to human HEMGN (hemogen). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 190.3), liver E14.5 (RPKM 184.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 24.73 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (46393989..46404183, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (46393989..46404183, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXB4 binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units.
Title: Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells.
EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment
Title: Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice.
Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
Title: Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:234918 (e-PCR)
- UniSTS:234918

RH136161 (e-PCR)
- UniSTS:210156

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hemogen

Names: hemopoietic gene protein; negative differentiation regulator protein; nuclear protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.