Fzd10 frizzled class receptor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fzd10provided by MGI
Official Full Name: frizzled class receptor 10provided by MGI
Primary source: MGI:MGI:2136761
See related: Ensembl:ENSMUSG00000081683 AllianceGenome:MGI:2136761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fz-10
Summary: Enables Wnt-protein binding activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in cell surface; cytoplasm; and nucleoplasm. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FZD10 (frizzled class receptor 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 5 G1.3; 5 67.67 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (128678170..128681157)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (128601106..128604093)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3beta/beta-Catenin Signaling and Induce Enteric Glial Cell Apoptosis.
Title: MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis.
the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis.
Title: FZD(10)-Gα(13) signalling axis points to a role of FZD(10) in CNS angiogenesis.
Results suggest that Frizzed 10 mediates Wnt1 signalling to determine sensory neural differentiation in Xenopus in vivo and in mouse cell culture.
Title: Frizzled-10 promotes sensory neuron development in Xenopus embryos.
Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
Title: Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development.
Frizzled10 expression is very strong during embryonic development of the CNS and may play an essential role in spatial and temporal regulation during neural development.
Title: Expression of Frizzled10 in mouse central nervous system.
Interprets Wnt signals during embryonic mesoderm and neural induction.
Title: Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.
Data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development.
Title: Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd10 (e-PCR), detects polymorphism
- UniSTS:506908

UniSTS:495988 (e-PCR)
- UniSTS:495988

Fzd10 (e-PCR), detects polymorphism
- UniSTS:495988

Fzd10 (e-PCR), detects polymorphism
- UniSTS:516474

Fzd10 (e-PCR), detects polymorphism
- UniSTS:508383

Fzd10 (e-PCR), detects polymorphism
- UniSTS:508384

NoName (e-PCR)
- UniSTS:548578

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: frizzled-10

Names: frizzled homolog 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175284.3 → NP_780493.1 frizzled-10 precursor

See identical proteins and their annotated locations for NP_780493.1

Status: PROVISIONAL

Source sequence(s)

AY509002

Consensus CDS

CCDS51652.1

UniProtKB/Swiss-Prot

Q8BKG4

UniProtKB/TrEMBL

Q149J3, Q71S95

Related

ENSMUSP00000114114.3, ENSMUST00000117102.4

Conserved Domains (2) summary

pfam01534
Location:219 → 536

Frizzled; Frizzled/Smoothened family membrane region

cl02447
Location:31 → 157

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain