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Pcdhb22 protocadherin beta 22 [ Mus musculus (house mouse) ]

Gene ID: 93893, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdhb22provided by MGI
Official Full Name
protocadherin beta 22provided by MGI
Primary source
MGI:MGI:2136760
See related
Ensembl:ENSMUSG00000073591 AllianceGenome:MGI:2136760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PcdhbV; Pcdhb15
Summary
Predicted to be involved in cell adhesion. Located in photoreceptor connecting cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and retina. Orthologous to human PCDHB15 (protocadherin beta 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
18 B3; 18 19.51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37651402..37657532)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37518353..37521419)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene STARR-seq mESC enhancer starr_44310 Neighboring gene STARR-seq mESC enhancer starr_44311 Neighboring gene protocadherin beta 20 Neighboring gene protocadherin beta 21 Neighboring gene STARR-seq mESC enhancer starr_44313 Neighboring gene STARR-seq mESC enhancer starr_44314 Neighboring gene STARR-positive B cell enhancer ABC_E4245 Neighboring gene solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 Neighboring gene TATA-box binding protein associated factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
  2. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
  3. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
  4. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
  5. Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity. Toyoda S, et al. Neuron, 2014 Apr 2. PMID 24698270

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protocadherin beta-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053147.4 → NP_444377.3  protocadherin beta-15 precursor

    See identical proteins and their annotated locations for NP_444377.3

    Status: VALIDATED

    Source sequence(s)
    AC020967
    Consensus CDS
    CCDS29187.1
    UniProtKB/TrEMBL
    Q8C8Z3, Q91XZ8
    Related
    ENSMUSP00000141521.2, ENSMUST00000192409.2
    Conserved Domains (3) summary
    cd11304
    Location:245 → 341
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:28 → 110
    Cadherin_2; Cadherin-like
    pfam16492
    Location:686 → 768
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37651402..37657532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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