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Pcdhb16 protocadherin beta 16 [ Mus musculus (house mouse) ]

Gene ID: 93887, updated on 11-Apr-2024

Summary

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Official Symbol
Pcdhb16provided by MGI
Official Full Name
protocadherin beta 16provided by MGI
Primary source
MGI:MGI:2136752
See related
Ensembl:ENSMUSG00000047910 AllianceGenome:MGI:2136752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcdhb8; PcdhbP
Summary
Predicted to be involved in cell adhesion. Located in photoreceptor connecting cilium; photoreceptor disc membrane; and postsynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human PCDHB13 (protocadherin beta 13) and PCDHB8 (protocadherin beta 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
18 B3; 18 19.5 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37610821..37616091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37477768..37483038)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin beta 14 Neighboring gene protocadherin beta 15 Neighboring gene protocadherin beta 17 Neighboring gene protocadherin beta 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems. Hirano K, et al. Front Mol Neurosci, 2012. PMID 22969705, Free PMC Article
  2. Protocadherins. Frank M, et al. Curr Opin Cell Biol, 2002 Oct. PMID 12231349
  3. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
  4. A unique role of cohesin-SA1 in gene regulation and development. Remeseiro S, et al. EMBO J, 2012 May 2. PMID 22415368, Free PMC Article
  5. A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development. Osipovich AB, et al. Development, 2021 Mar 21. PMID 33653874, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
involved_in synapse assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor disc membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protocadherin beta 16
Names
Protocadherin-betaP
cell-cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053141.3 → NP_444371.3  protocadherin beta 16 precursor

    See identical proteins and their annotated locations for NP_444371.3

    Status: VALIDATED

    Source sequence(s)
    AK036829, BC116625, BP762533, CJ182908
    Consensus CDS
    CCDS29182.1
    UniProtKB/TrEMBL
    Q14BM8, Q8CB45, Q91Y03
    Related
    ENSMUSP00000056347.6, ENSMUST00000051442.7
    Conserved Domains (3) summary
    cd11304
    Location:248 → 344
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:32 → 113
    Cadherin_2; Cadherin-like
    pfam16492
    Location:687 → 770
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    37610821..37616091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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