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Uchl4 ubiquitin carboxyl-terminal esterase L4 [ Mus musculus (house mouse) ]

Gene ID: 93841, updated on 9-Dec-2024

Summary

Official Symbol
Uchl4provided by MGI
Official Full Name
ubiquitin carboxyl-terminal esterase L4provided by MGI
Primary source
MGI:MGI:1890440
See related
Ensembl:ENSMUSG00000035337 AllianceGenome:MGI:1890440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Predicted to be involved in protein catabolic process and protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; jaw; sensory organ; submandibular gland primordium; and thymus primordium. Orthologous to human UCHL3 (ubiquitin C-terminal hydrolase L3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See Uchl4 in Genome Data Viewer
Location:
9 C; 9 34.58 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64142483..64143644)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64235201..64236362)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene predicted gene, 22455 Neighboring gene ribosomal protein L4 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene timeless interacting protein Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity  
enables cysteine-type deubiquitinase activity  
enables cysteine-type deubiquitinase activity  
enables peptidase activity  
enables ubiquitin binding  
Process Evidence Code Pubs
involved_in protein catabolic process  
involved_in protein catabolic process  
involved_in protein deubiquitination  
involved_in ubiquitin-dependent protein catabolic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in nucleoplasm  

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L4
Names
UCH-L4
ubiquitin thioesterase L4
NP_291085.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033607.1NP_291085.1  ubiquitin carboxyl-terminal hydrolase isozyme L4

    See identical proteins and their annotated locations for NP_291085.1

    Status: PROVISIONAL

    Source sequence(s)
    AB035420
    Consensus CDS
    CCDS23278.1
    UniProtKB/Swiss-Prot
    P58321
    UniProtKB/TrEMBL
    B2RTM4
    Related
    ENSMUSP00000045208.4, ENSMUST00000039011.4
    Conserved Domains (1) summary
    cd09616
    Location:6230
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64142483..64143644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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