U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nipa2 non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human) [ Mus musculus (house mouse) ]

Gene ID: 93790, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nipa2provided by MGI
Official Full Name
non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)provided by MGI
Primary source
MGI:MGI:1913918
See related
Ensembl:ENSMUSG00000030452 AllianceGenome:MGI:1913918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600017P10Rik; 3830408P04Rik
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Involved in magnesium ion transport. Located in early endosome and plasma membrane. Orthologous to human NIPA2 (NIPA magnesium transporter 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 13.6), bladder adult (RPKM 9.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 B5; 7 33.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (55581014..55612241, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (55931266..55962493, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 5 Neighboring gene STARR-seq mESC enhancer starr_18956 Neighboring gene STARR-positive B cell enhancer mm9_chr7:63113113-63113414 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_18959 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene RIKEN cDNA A230056P14 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:63223630-63223930 Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human) Neighboring gene ribosomal protein S12-like 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis. Zhao W, et al. Sci Rep, 2020 Feb 20. PMID 32080264, Free PMC Article
  2. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Chai JH, et al. Am J Hum Genet, 2003 Oct. PMID 14508708, Free PMC Article
  3. Functional characterization of NIPA2, a selective Mg2+ transporter. Goytain A, et al. Am J Physiol Cell Physiol, 2008 Oct. PMID 18667602
  4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis.
    Title: NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis.
  2. The isolation and characterization of Nipa2 in mouse distal convoluted tubule cells are reported.
    Title: Functional characterization of NIPA2, a selective Mg2+ transporter.
  3. indentification on mouse chromosome 7C
    Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
magnesium transporter NIPA2
Names
non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256130.1 → NP_001243059.1  magnesium transporter NIPA2 isoform 1

    See identical proteins and their annotated locations for NP_001243059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AB041581, AI119710, AK041427, BK001121, BY144304
    Consensus CDS
    CCDS21316.1
    UniProtKB/Swiss-Prot
    Q3U3I0, Q9JJC8
    UniProtKB/TrEMBL
    Q9D0N5
    Related
    ENSMUSP00000032635.8, ENSMUST00000032635.14
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  2. NM_001256131.1 → NP_001243060.1  magnesium transporter NIPA2 isoform 1

    See identical proteins and their annotated locations for NP_001243060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AI119710, AK028734, AK041427, BK001121, BY144304
    Consensus CDS
    CCDS21316.1
    UniProtKB/Swiss-Prot
    Q3U3I0, Q9JJC8
    UniProtKB/TrEMBL
    Q9D0N5
    Related
    ENSMUSP00000113727.2, ENSMUST00000117812.8
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  3. NM_001256132.1 → NP_001243061.1  magnesium transporter NIPA2 isoform 1

    See identical proteins and their annotated locations for NP_001243061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AI119710, AK008106, AK041427, BK001121
    Consensus CDS
    CCDS21316.1
    UniProtKB/Swiss-Prot
    Q3U3I0, Q9JJC8
    UniProtKB/TrEMBL
    Q9D0N5
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  4. NM_001256133.1 → NP_001243062.1  magnesium transporter NIPA2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream AUG start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI119710, AK008106, AK041427, AV495155, BK001121
    UniProtKB/TrEMBL
    Q9D0N5
    Conserved Domains (1) summary
    cl23754
    Location:1 → 237
    EamA; EamA-like transporter family

  5. NM_023647.6 → NP_076136.2  magnesium transporter NIPA2 isoform 1

    See identical proteins and their annotated locations for NP_076136.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-4 encode the same isoform (1).
    Source sequence(s)
    AI119710, AK028734, AK041427, BK001121
    Consensus CDS
    CCDS21316.1
    UniProtKB/Swiss-Prot
    Q3U3I0, Q9JJC8
    UniProtKB/TrEMBL
    Q9D0N5
    Related
    ENSMUSP00000114020.2, ENSMUST00000119201.8
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    55581014..55612241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541324.4 → XP_006541387.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_006541387.1

    UniProtKB/Swiss-Prot
    Q3U3I0, Q9JJC8
    UniProtKB/TrEMBL
    Q9D0N5
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJC8.1 GenPept UniProtKB/Swiss-Prot:Q9JJC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous