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Lztfl1 leucine zipper transcription factor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 93730, updated on 5-Mar-2024

Summary

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Official Symbol
Lztfl1provided by MGI
Official Full Name
leucine zipper transcription factor-like 1provided by MGI
Primary source
MGI:MGI:1934860
See related
Ensembl:ENSMUSG00000025245 AllianceGenome:MGI:1934860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5530402H04Rik; 6130400H19Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of protein localization to ciliary membrane. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Biedl syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F4; 9 74.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123523469..123546690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123694404..123717625, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 20A Neighboring gene STARR-seq mESC enhancer starr_25570 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626087-123626387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626696-123626997 Neighboring gene STARR-seq mESC enhancer starr_25571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123663531-123663880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123665948-123666172 Neighboring gene predicted gene 17021 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123693813-123694114 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene FYVE and coiled-coil domain containing 1 Neighboring gene C-X-C motif chemokine receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice. Jiang J, et al. J Genet Genomics, 2016 Jun 20. PMID 27312011, Free PMC Article
  2. Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training. Sakurai T, et al. Biochem Biophys Res Commun, 2011 Dec 9. PMID 22093827
  3. Limited time window for retinal gene therapy in a preclinical model of ciliopathy. Datta P, et al. Hum Mol Genet, 2020 Aug 11. PMID 32568387, Free PMC Article
  4. Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. Wei Q, et al. J Mol Cell Biol, 2018 Oct 1. PMID 30423168, Free PMC Article
  5. LZTFL1 suppresses gastric cancer cell migration and invasion through regulating nuclear translocation of β-catenin. Wang L, et al. J Cancer Res Clin Oncol, 2014 Dec. PMID 25005785

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
    Title: Anti-inflammation of LZTFL1 knockdown in OVA-induced asthmatic mice: Through ERK/GATA3 signaling pathway.
  2. Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.
    Title: Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.
  3. Limited time window for retinal gene therapy in a preclinical model of ciliopathy.
    Title: Limited time window for retinal gene therapy in a preclinical model of ciliopathy.
  4. Lztfl1 is required for leptin signaling in the hypothalamus.Lztfl1 functions downstream of leptin receptor in regulation of actin/cytoskeleton dynamics.
    Title: Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons.
  5. LZTFL1 is a cilium protein and regulates animal weight and photoreceptor connecting cilium function probably by controlling microtubule assembly and protein trafficking in cilia
    Title: Depletion of BBS Protein LZTFL1 Affects Growth and Causes Retinal Degeneration in Mice.
  6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling
    Title: A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
  7. the expression levels of leucine zipper transcription factor-like protein 1 (Lztfl1) mRNA were significantly higher in SAMP8 mice subjected to exercise training.
    Title: Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC106871

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein localization to cilium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine zipper transcription factor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033322.3 → NP_201579.1  leucine zipper transcription factor-like protein 1

    See identical proteins and their annotated locations for NP_201579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) reprsents the protein-coding variant.
    Source sequence(s)
    AK054003, AK147312, BE979461
    Consensus CDS
    CCDS40818.1
    UniProtKB/Swiss-Prot
    Q8BRX8, Q8CDS2, Q9JHQ5
    UniProtKB/TrEMBL
    Q8CDG8
    Related
    ENSMUSP00000026274.8, ENSMUST00000026274.14
    Conserved Domains (1) summary
    pfam15294
    Location:20 → 294
    Leu_zip; Leucine zipper

RNA

  1. NR_151689.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK147312, BE979461
    Related
    ENSMUST00000165754.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123523469..123546690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512403.5 → XP_006512466.1  leucine zipper transcription factor-like protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8CDG8
    Related
    ENSMUSP00000132359.2, ENSMUST00000168921.2
    Conserved Domains (1) summary
    pfam15294
    Location:3 → 277
    Leu_zip; Leucine zipper
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHQ5.1 GenPept UniProtKB/Swiss-Prot:Q9JHQ5

Gene LinkOut

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