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Pabpc5 poly(A) binding protein, cytoplasmic 5 [ Mus musculus (house mouse) ]

Gene ID: 93728, updated on 5-Mar-2024

Summary

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Official Symbol
Pabpc5provided by MGI
Official Full Name
poly(A) binding protein, cytoplasmic 5provided by MGI
Primary source
MGI:MGI:2136401
See related
Ensembl:ENSMUSG00000034732 AllianceGenome:MGI:2136401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C820015E17
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in brain and sensory organ. Orthologous to human PABPC5 (poly(A) binding protein cytoplasmic 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X E1; X 49.58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (118836893..118839862)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (119927196..119930165)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene STARR-seq mESC enhancer starr_47849 Neighboring gene predicted gene, 26182 Neighboring gene STARR-seq mESC enhancer starr_47850 Neighboring gene STARR-seq mESC enhancer starr_47851 Neighboring gene STARR-seq mESC enhancer starr_47852 Neighboring gene STARR-seq mESC enhancer starr_47853 Neighboring gene STARR-seq mESC enhancer starr_47854 Neighboring gene STARR-seq mESC enhancer starr_47855 Neighboring gene S-adenosylhomocysteine hydrolase pseudogene Neighboring gene SET translocation pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. Blanco P, et al. Genomics, 2001 May 15. PMID 11374897
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC130340, MGC130341

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053114.2 → NP_444344.1  polyadenylate-binding protein 5

    See identical proteins and their annotated locations for NP_444344.1

    Status: VALIDATED

    Source sequence(s)
    AK050551
    Consensus CDS
    CCDS30369.1
    UniProtKB/TrEMBL
    Q8C7D3
    Related
    ENSMUSP00000047756.3, ENSMUST00000040961.3
    Conserved Domains (5) summary
    cd12378
    Location:21 → 97
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:103 → 178
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:197 → 276
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    TIGR01661
    Location:28 → 270
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:300 → 376
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    118836893..118839862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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