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Ice2 interactor of little elongation complex ELL subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 93697, updated on 21-Apr-2024

Summary

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Official Symbol
Ice2provided by MGI
Official Full Name
interactor of little elongation complex ELL subunit 2provided by MGI
Primary source
MGI:MGI:2135947
See related
Ensembl:ENSMUSG00000032235 AllianceGenome:MGI:2135947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Narg2; B230343B06Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human ICE2 (interactor of little elongation complex ELL subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.9), limb E14.5 (RPKM 3.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 38.58 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69305185..69340360)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (69397904..69433078)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAR-related orphan receptor alpha Neighboring gene predicted gene, 46153 Neighboring gene predicted gene 15511 Neighboring gene STARR-seq mESC enhancer starr_24519 Neighboring gene purine-nucleoside phosphorylase pseudogene Neighboring gene predicted gene 7802

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. Sugiura N, et al. Eur J Biochem, 2004 Dec. PMID 15606750
  2. Murine equivalent of the human histo-blood group ABO gene is a cis-AB gene and encodes a glycosyltransferase with both A and B transferase activity. Yamamoto M, et al. J Biol Chem, 2001 Apr 27. PMID 11278752
  3. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. Sugiura N, et al. J Biol Chem, 2001 Apr 27. PMID 11297529
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in histone locus body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
little elongation complex subunit 2
Names
NMDA receptor-regulated gene 2
NMDA receptor-regulated protein 2
interactor of little elongator complex ELL subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145618.3 → NP_663593.2  little elongation complex subunit 2

    See identical proteins and their annotated locations for NP_663593.2

    Status: VALIDATED

    Source sequence(s)
    BC068183
    Consensus CDS
    CCDS23315.1
    UniProtKB/Swiss-Prot
    B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
    Related
    ENSMUSP00000034761.9, ENSMUST00000034761.15
    Conserved Domains (2) summary
    PHA03247
    Location:429 → 473
    PHA03247; large tegument protein UL36; Provisional
    pfam10505
    Location:728 → 936
    NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69305185..69340360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155420.1 → XP_036011313.1  little elongation complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
    Conserved Domains (2) summary
    PHA03247
    Location:429 → 473
    PHA03247; large tegument protein UL36; Provisional
    pfam10505
    Location:728 → 936
    NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

  2. XM_006511573.5 → XP_006511636.1  little elongation complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006511636.1

    UniProtKB/Swiss-Prot
    B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
    Conserved Domains (2) summary
    PHA03247
    Location:429 → 473
    PHA03247; large tegument protein UL36; Provisional
    pfam10505
    Location:728 → 936
    NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

  3. XM_006511575.5 → XP_006511638.1  little elongation complex subunit 2 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:296 → 340
    PHA03247; large tegument protein UL36; Provisional
    pfam10505
    Location:595 → 803
    NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

  4. XM_006511574.5 → XP_006511637.1  little elongation complex subunit 2 isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:394 → 438
    PHA03247; large tegument protein UL36; Provisional
    pfam10505
    Location:693 → 901
    NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

RNA

  1. XR_004935620.1 RNA Sequence

  2. XR_004935618.1 RNA Sequence

  3. XR_004935619.1 RNA Sequence

  4. XR_379471.4 RNA Sequence

  5. XR_004935621.1 RNA Sequence

  6. XR_003948073.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UZ18.2 GenPept UniProtKB/Swiss-Prot:Q3UZ18

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