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Gpr45 G protein-coupled receptor 45 [ Mus musculus (house mouse) ]

Gene ID: 93690, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr45provided by MGI
Official Full Name
G protein-coupled receptor 45provided by MGI
Primary source
MGI:MGI:2135882
See related
Ensembl:ENSMUSG00000041907 AllianceGenome:MGI:2135882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9230112G11Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be integral component of membrane. Orthologous to human GPR45 (G protein-coupled receptor 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 1.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 21.88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (42992032..43074611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (42952872..43035451)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53552 Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene predicted gene, 23126 Neighboring gene predicted gene, 39633 Neighboring gene STARR-seq mESC enhancer starr_00772 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene transforming growth factor, beta receptor associated protein 1 Neighboring gene predicted gene 28782 Neighboring gene RIKEN cDNA 8430432A02 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. Cui J, et al. J Clin Invest, 2016 Sep 1. PMID 27500489, Free PMC Article
  2. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. Hanchate NK, et al. J Neurosci, 2012 Jan 18. PMID 22262891, Free PMC Article
  3. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR45 is a regulator of POMC signaling and energy expenditure, which suggests that it may be a potential intervention target to combat obesity
    Title: Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
  2. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation
    Title: Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 45
Names
PSP24-1
PSP24-alpha
PSP24alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053107.4 → NP_444337.3  probable G-protein coupled receptor 45

    See identical proteins and their annotated locations for NP_444337.3

    Status: VALIDATED

    Source sequence(s)
    AK039769, AK054151, BC118506
    Consensus CDS
    CCDS14919.1
    UniProtKB/Swiss-Prot
    Q9EQQ4
    UniProtKB/TrEMBL
    Q148B5, Q8CA29
    Related
    ENSMUSP00000135986.2, ENSMUST00000179766.3
    Conserved Domains (2) summary
    cd14964
    Location:36 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35 → 336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    42992032..43074611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154462.1 → XP_036010355.1  probable G-protein coupled receptor 45 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQQ4
    UniProtKB/TrEMBL
    Q148B5, Q8CA29
    Conserved Domains (2) summary
    cd14964
    Location:36 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35 → 336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006496346.4 → XP_006496409.1  probable G-protein coupled receptor 45 isoform X1

    See identical proteins and their annotated locations for XP_006496409.1

    UniProtKB/Swiss-Prot
    Q9EQQ4
    UniProtKB/TrEMBL
    Q148B5, Q8CA29
    Conserved Domains (2) summary
    cd14964
    Location:36 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35 → 336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_017312993.3 → XP_017168482.1  probable G-protein coupled receptor 45 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQQ4
    UniProtKB/TrEMBL
    Q148B5, Q8CA29
    Conserved Domains (2) summary
    cd14964
    Location:36 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35 → 336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_006496347.4 → XP_006496410.1  probable G-protein coupled receptor 45 isoform X1

    See identical proteins and their annotated locations for XP_006496410.1

    UniProtKB/Swiss-Prot
    Q9EQQ4
    UniProtKB/TrEMBL
    Q148B5, Q8CA29
    Conserved Domains (2) summary
    cd14964
    Location:36 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35 → 336
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQQ4.1 GenPept UniProtKB/Swiss-Prot:Q9EQQ4

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