U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd163 CD163 antigen [ Mus musculus (house mouse) ]

Gene ID: 93671, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Cd163provided by MGI
Official Full Name
CD163 antigenprovided by MGI
Primary source
MGI:MGI:2135946
See related
Ensembl:ENSMUSG00000008845 AllianceGenome:MGI:2135946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD163v2; CD163v3
Summary
Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to act upstream of or within acute-phase response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including gut; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 2.3) and 20 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 F2; 6 59.13 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124281596..124307488)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124304636..124330529)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene predicted gene, 25311 Neighboring gene predicted gene, 52877 Neighboring gene RIKEN cDNA 1700013D24 gene Neighboring gene RIKEN cDNA 1700027F06 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice. Fujiwara Y, et al. Clin Transl Immunology, 2020. PMID 33005412, Free PMC Article
  2. IsdB antibody-mediated sepsis following S. aureus surgical site infection. Nishitani K, et al. JCI Insight, 2020 Oct 2. PMID 33004694, Free PMC Article
  3. Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis. Svendsen P, et al. Sci Rep, 2020 Jul 24. PMID 32710083, Free PMC Article
  4. The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes. Leclerc JL, et al. J Cereb Blood Flow Metab, 2018 Feb. PMID 28358264, Free PMC Article
  5. Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption. Etzerodt A, et al. Antioxid Redox Signal, 2013 Jun 10. PMID 22793784

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
    Title: TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
  2. ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-kappaB pathway.
    Title: ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.
  3. CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
    Title: CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
  4. Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
    Title: Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
  5. Study observed macrophage-induced tumor cell proliferation in cocultures of human monocyte-derived macrophages and leiomyosarcoma and myxofibrosarcoma human and mouse cell lines, which was abrogated by silencing of CD163. Tumor development of sarcoma cells in CD163-deficient mice was significantly abrogated in comparison with wild-type mice.
    Title: CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma.
  6. CD163 has a role in angiogenesis and vascular permeability with inflammation in atherosclerosis
    Title: CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
  7. While it is unclear why CD163 deficiency is initially beneficial, the late injurious effects are consistent with the key anti-inflammatory role of CD163 in the recovery phase of tissue damage
    Title: The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.
  8. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia
    Title: A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.
  9. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.
    Title: Monocyte CD163 is altered in association with diabetic complications: possible protective role.
  10. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation.
    Title: CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acute-phase response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
scavenger receptor cysteine-rich type 1 protein M130

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170395.1 → NP_001163866.1  scavenger receptor cysteine-rich type 1 protein M130 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001163866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS51905.1
    UniProtKB/TrEMBL
    B7ZMW6
    Related
    ENSMUSP00000108160.3, ENSMUST00000112541.8
    Conserved Domains (2) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:724 → 819
    SRCR; Scavenger receptor cysteine-rich domain

  2. NM_053094.2 → NP_444324.2  scavenger receptor cysteine-rich type 1 protein M130 isoform 2 precursor

    See identical proteins and their annotated locations for NP_444324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC124470
    Consensus CDS
    CCDS20516.1
    UniProtKB/Swiss-Prot
    A6H691, Q2VLH5, Q2VLH6, Q99MX8
    Related
    ENSMUSP00000032234.3, ENSMUST00000032234.5
    Conserved Domains (2) summary
    smart00202
    Location:719 → 819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:724 → 819
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124281596..124307488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506800.5 → XP_006506863.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

    Conserved Domains (1) summary
    smart00202
    Location:691 → 791
    SR; Scavenger receptor Cys-rich
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2VLH6.2 GenPept UniProtKB/Swiss-Prot:Q2VLH6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous