Tac4 tachykinin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tac4provided by MGI
Official Full Name: tachykinin 4provided by MGI
Primary source: MGI:MGI:1931130
See related: Ensembl:ENSMUSG00000020872 AllianceGenome:MGI:1931130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PPT-C
Summary: Enables receptor ligand activity; substance K receptor binding activity; and substance P receptor binding activity. Involved in positive regulation of cytosolic calcium ion concentration. Acts upstream of or within positive regulation of saliva secretion and tachykinin receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; mammary gland; skin; spleen; and stomach. Orthologous to human TAC4 (tachykinin precursor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95152355..95160091)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95261529..95269265)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results provide the first evidence for an anxiolytic and anti-depressant-like actions of HK-1 through a presently unknown target-mediated mechanism
Title: Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice.
hemokinin-1 plays a crucial pro-inflammatory role in the lung by increasing inflammatory cell activities, and might also be a specific regulator of lymphocyte functions.
Title: Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse.
Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis.
Title: Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A.
Title: Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice.
HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor
Title: Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
Our findings suggest a role for TAC4 in cell differentiation, and represent a regulatory bridge between the nervous system and the immune system.
Title: Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes.
cultures from TAC4(-/-) bone marrow, sorted "fraction B" pro-B cells or purified long-term reconstituting stem cells, contain higher numbers of pro-B cells compared with controls, suggesting an inhibitory role for HK-1 on developing B cells
Title: Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.
Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P.
Title: Regulatory mechanisms in the differential expression of Hemokinin-1.
mouse hemokinin 1 and mouse hemokinin 1(2-11) are tachykinin NK(1) receptor-preferring uterotonic agonists in non-pregnant mice but lack action at the myometrial tachykinin NK(2) receptors present in late pregnant mice
Title: Functional characterisation of hemokinin-1 in mouse uterus.
Preprotachykinin (PPT)-C genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function.
Title: A role for tachykinins in female mouse and rat reproductive function.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489260

AW489379 (e-PCR)
- UniSTS:180297

Tac4 (e-PCR), detects polymorphism
- UniSTS:463473

NoName (e-PCR)
- UniSTS:236700

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables substance K receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance P receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables substance P receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables substance P receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of saliva secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tachykinin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tachykinin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tachykinin-4

Names: hemokinin I (HK-1); preprotachykinin-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.