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TRIP10 thyroid hormone receptor interactor 10 [ Homo sapiens (human) ]

Gene ID: 9322, updated on 3-Apr-2024

Summary

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Official Symbol
TRIP10provided by HGNC
Official Full Name
thyroid hormone receptor interactor 10provided by HGNC
Primary source
HGNC:HGNC:12304
See related
Ensembl:ENSG00000125733 MIM:604504; AllianceGenome:HGNC:12304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STP; CIP4; HSTP; STOT; TRIP-10
Summary
Enables identical protein binding activity. Predicted to be involved in actin cytoskeleton organization; endocytosis; and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues See more
Orthologs
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Genomic context

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See TRIP10 in Genome Data Viewer
Location:
19p13.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6739680..6751530)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6729071..6740925)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6739691..6751541)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697003-6697504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6697505-6698004 Neighboring gene complement C3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6727893-6728394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6728395-6728894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9961 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:6735174-6735942 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736406-6736560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6736926-6737087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6738248-6739016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6739785-6740552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6742783-6743702 Neighboring gene G protein-coupled receptor 108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:6745754-6746254 Neighboring gene uncharacterized LOC124904623 Neighboring gene microRNA 6791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6760841-6761341 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6764936-6765836 Neighboring gene SH2 domain containing 3A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6772949-6773449 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13864 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:6782716-6782888 Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene MPRA-validated peak3307 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6801723-6802243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13866 Neighboring gene Sharpr-MPRA regulatory region 13171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer. Fang L, et al. PLoS One, 2021. PMID 34570775, Free PMC Article
  2. Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis. Tonucci FM, et al. Cancer Lett, 2019 Oct 1. PMID 31319138
  3. CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling. Meng DF, et al. J Exp Clin Cancer Res, 2017 Jan 28. PMID 28129778, Free PMC Article
  4. CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis. Cerqueira OL, et al. Oncotarget, 2015 Apr 20. PMID 25823823, Free PMC Article
  5. The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination. Rolland Y, et al. Dev Cell, 2014 Sep 8. PMID 25203208

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer.
    Title: Low expression of CIP4 in predicting worse overall survival: A potential biomarker for laryngeal cancer.
  2. CIP4 PKA phosphorylation is associated with cancer cell invasiveness and metastasis.
    Title: Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis.
  3. FBP17 and CIP4 prime the membrane of resting cells for fast endophilin-mediated endocytosis by recruiting the 5'-lipid phosphatase SHIP2 and lamellipodin to mediate the local production of phosphatidylinositol-3,4-bisphosphate and endophilin pre-enrichment.
    Title: FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
  4. In cultured colorectal cancer (CRC) cells, knockdown of AKAP-9 inhibited cell proliferation, invasion, and migration. AKAP-9 deficiency also attenuated CRC tumor growth and metastasis in vivo. Mechanistically, AKAP-9 interacted with cdc42 interacting protein 4 (CIP4) and regulated its expression.
    Title: AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4.
  5. Data show that CIP4 is highly expressed in nasopharyngeal carcinoma (NPC) tissues and is associated with poor prognosis. Also, the study provides evidence that CIP4 plays an important role in the promotion of NPC metastasis by mediating invadopodia formation and activating the EGFR pathway.
    Title: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling.
  6. results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
    Title: Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells.
  7. CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis.
    Title: CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
  8. CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma.
    Title: CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis.
  9. CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors
    Title: The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.
  10. CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease.
    Title: CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell communication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cdc42-interacting protein 4
Names
TR-interacting protein 10
protein Felic
salt tolerant protein
salt tolerator
thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288962.2 → NP_001275891.1  cdc42-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001275891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008760, AF502289, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS74271.1
    UniProtKB/Swiss-Prot
    B2R8A6, B7WP22, D6W645, O15184, Q15642, Q53G22, Q5TZN1, Q6FI24, Q8NFL1, Q8TCY1, Q8TDX3, Q96RJ1
    UniProtKB/TrEMBL
    A7VJC9
    Related
    ENSP00000320117.7, ENST00000313244.14
    Conserved Domains (3) summary
    cd07653
    Location:5 → 257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395 → 475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:544 → 598
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

  2. NM_001288963.3 → NP_001275892.1  cdc42-interacting protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001275892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, and uses an alternate splice site in the 3' coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) lacks an internal segment and has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC008760, AF380114, AK313296, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS74272.1
    UniProtKB/TrEMBL
    A7VJC9, W4VSQ9
    Related
    ENSP00000469360.1, ENST00000596758.5
    Conserved Domains (2) summary
    cd07653
    Location:5 → 257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339 → 419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

  3. NM_004240.4 → NP_004231.1  cdc42-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_004231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC008760, AK313296, AY081141, CB997985, DB198268
    Consensus CDS
    CCDS12172.1
    UniProtKB/TrEMBL
    A7VJC9
    Related
    ENSP00000320493.6, ENST00000313285.12
    Conserved Domains (3) summary
    cd07653
    Location:5 → 257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339 → 419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:488 → 542
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

RNA

  1. NR_110231.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB072596, AC008760, AK313296, AY081141, CB997985, DB198268

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    6739680..6751530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722940.2 → XP_006723003.1  cdc42-interacting protein 4 isoform X1

    Conserved Domains (2) summary
    cd07653
    Location:5 → 257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395 → 475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

  2. XM_005259683.3 → XP_005259740.1  cdc42-interacting protein 4 isoform X2

    UniProtKB/TrEMBL
    M0R2H7
    Related
    ENSP00000472580.1, ENST00000600677.5
    Conserved Domains (1) summary
    cd07653
    Location:5 → 257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    6729071..6740925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322670.1 → XP_054178645.1  cdc42-interacting protein 4 isoform X1

  2. XM_054322671.1 → XP_054178646.1  cdc42-interacting protein 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15642.3 GenPept UniProtKB/Swiss-Prot:Q15642

Gene LinkOut

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