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ZNF561 zinc finger protein 561 [ Homo sapiens (human) ]

Gene ID: 93134, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF561provided by HGNC
Official Full Name
zinc finger protein 561provided by HGNC
Primary source
HGNC:HGNC:28684
See related
Ensembl:ENSG00000171469 AllianceGenome:HGNC:28684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 8.9), endometrium (RPKM 7.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9607329..9621232, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9733531..9747444, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9718005..9731908, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr19:9677059-9677560 Neighboring gene zinc finger protein 121 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9692318-9693131 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9693132-9693944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9694759-9695570 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9700111-9700757 Neighboring gene uncharacterized LOC105376914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9731087-9731669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13932 Neighboring gene ZNF561 antisense RNA 1 (head to head) Neighboring gene zinc finger protein 562 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:9784745-9785944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Tiemann K, et al. Oncogene, 2019 Apr. PMID 30575818, Free PMC Article
  2. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  3. The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside. Sun X, et al. J Ginseng Res, 2022 Mar. PMID 35509820, Free PMC Article
  4. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330365.2 → NP_001317294.1  zinc finger protein 561 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008759, AK122974, HY015530
    Consensus CDS
    CCDS82286.1
    UniProtKB/TrEMBL
    A8KAD9
    Related
    ENSP00000393074.1, ENST00000424629.5
    Conserved Domains (3) summary
    COG5048
    Location:202 → 398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 122
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_152289.3 → NP_689502.2  zinc finger protein 561 isoform 1

    See identical proteins and their annotated locations for NP_689502.2

    Status: VALIDATED

    Source sequence(s)
    AK122974, BC032668, BP230901, CA415776
    Consensus CDS
    CCDS12216.2
    UniProtKB/Swiss-Prot
    B4E2Q8, Q6PJS0, Q8N587
    Related
    ENSP00000303915.3, ENST00000302851.8
    Conserved Domains (4) summary
    COG5048
    Location:271 → 467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:174 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:40 → 80
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9607329..9621232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722938.4 → XP_006723001.1  zinc finger protein 561 isoform X1

    See identical proteins and their annotated locations for XP_006723001.1

    Conserved Domains (7) summary
    smart00349
    Location:47 → 102
    KRAB; krueppel associated box
    COG5048
    Location:277 → 473
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:180 → 197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287 → 309
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:47 → 86
    KRAB; KRAB box
    pfam13465
    Location:442 → 465
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011528434.3 → XP_011526736.1  zinc finger protein 561 isoform X1

    See identical proteins and their annotated locations for XP_011526736.1

    Conserved Domains (7) summary
    smart00349
    Location:47 → 102
    KRAB; krueppel associated box
    COG5048
    Location:277 → 473
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:180 → 197
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287 → 309
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:47 → 86
    KRAB; KRAB box
    pfam13465
    Location:442 → 465
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005260150.3 → XP_005260207.1  zinc finger protein 561 isoform X2

    See identical proteins and their annotated locations for XP_005260207.1

    UniProtKB/Swiss-Prot
    B4E2Q8, Q6PJS0, Q8N587
    Conserved Domains (4) summary
    COG5048
    Location:271 → 467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:174 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:40 → 80
    KRAB; KRAB box

  4. XM_047439708.1 → XP_047295664.1  zinc finger protein 561 isoform X1

  5. XM_047439709.1 → XP_047295665.1  zinc finger protein 561 isoform X2

    UniProtKB/Swiss-Prot
    B4E2Q8, Q6PJS0, Q8N587

  6. XM_047439710.1 → XP_047295666.1  zinc finger protein 561 isoform X3

  7. XM_024451781.2 → XP_024307549.1  zinc finger protein 561 isoform X4

    UniProtKB/TrEMBL
    A8KAD9
    Conserved Domains (3) summary
    COG5048
    Location:202 → 398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 122
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_047439712.1 → XP_047295668.1  zinc finger protein 561 isoform X5

  9. XM_017027479.3 → XP_016882968.1  zinc finger protein 561 isoform X4

    UniProtKB/TrEMBL
    A8KAD9
    Conserved Domains (3) summary
    COG5048
    Location:202 → 398
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:105 → 122
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_047439711.1 → XP_047295667.1  zinc finger protein 561 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9733531..9747444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322662.1 → XP_054178637.1  zinc finger protein 561 isoform X2

    UniProtKB/Swiss-Prot
    B4E2Q8, Q6PJS0, Q8N587

  2. XM_054322660.1 → XP_054178635.1  zinc finger protein 561 isoform X1

  3. XM_054322661.1 → XP_054178636.1  zinc finger protein 561 isoform X1

  4. XM_054322663.1 → XP_054178638.1  zinc finger protein 561 isoform X2

    UniProtKB/Swiss-Prot
    B4E2Q8, Q6PJS0, Q8N587

  5. XM_054322664.1 → XP_054178639.1  zinc finger protein 561 isoform X3

  6. XM_054322666.1 → XP_054178641.1  zinc finger protein 561 isoform X4

    UniProtKB/TrEMBL
    A8KAD9

  7. XM_054322668.1 → XP_054178643.1  zinc finger protein 561 isoform X5

  8. XM_054322667.1 → XP_054178642.1  zinc finger protein 561 isoform X4

    UniProtKB/TrEMBL
    A8KAD9

  9. XM_054322665.1 → XP_054178640.1  zinc finger protein 561 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N587.2 GenPept UniProtKB/Swiss-Prot:Q8N587

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