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NEURL3 neuralized E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 93082, updated on 5-Mar-2024

Summary

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Official Symbol
NEURL3provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:25162
See related
Ensembl:ENSG00000163121 MIM:617206; AllianceGenome:HGNC:25162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINCR; RNF132
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in salivary gland (RPKM 4.9), kidney (RPKM 1.8) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See NEURL3 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96497646..96508109, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (97004264..97014728, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97163383..97173846, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96991242-96991742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:97000977-97001818 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:97001819-97002660 Neighboring gene ITPRIP like 1 Neighboring gene non-SMC condensin I complex subunit H Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:97087565-97088066 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:97093193-97094392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:97128139-97128886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97151159-97151851 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:97158713-97159372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97162590-97163590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97163591-97164590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11767 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97190085-97190604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11769 Neighboring gene uncharacterized LOC105373496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97196747-97197538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:97197539-97198328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11771 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16221 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:97204265-97204810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16222 Neighboring gene AT-rich interaction domain 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation.
    Title: The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEURL3
Names
RING-type E3 ubiquitin transferase NEURL3
lung-inducible neuralized-related C3CH4 RING domain protein
neuralized homolog 3 pseudogene
neuralized-like protein 3
NP_001272414.1
NP_001272415.1
XP_011510480.1
XP_011510481.1
XP_047302299.1
XP_054200551.1
XP_054200552.1
XP_054200553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285485.2 → NP_001272414.1  E3 ubiquitin-protein ligase NEURL3 isoform a

    See identical proteins and their annotated locations for NP_001272414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC013270, CA311039, DC406186, HY288910
    Consensus CDS
    CCDS74542.1
    UniProtKB/Swiss-Prot
    Q96EH8
    Related
    ENSP00000478591.1, ENST00000451794.6
    Conserved Domains (4) summary
    smart00588
    Location:16 → 138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:20 → 85
    Neuralized; Neuralized
    pfam13920
    Location:200 → 247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19 → 171
    SPRY; SPRY domain

  2. NM_001285486.2 → NP_001272415.1  E3 ubiquitin-protein ligase NEURL3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform b) uses a downstream, in-frame AUG and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL389981, DC406186
    Consensus CDS
    CCDS74541.1
    UniProtKB/TrEMBL
    A0A087WVI2
    Related
    ENSP00000479456.1, ENST00000310865.7

RNA

  1. NR_104346.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC012317

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    96497646..96508109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512179.3 → XP_011510481.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_011510481.1

    UniProtKB/Swiss-Prot
    Q96EH8
    Conserved Domains (4) summary
    smart00588
    Location:16 → 138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:20 → 85
    Neuralized; Neuralized
    pfam13920
    Location:200 → 247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19 → 171
    SPRY; SPRY domain

  2. XM_011512178.3 → XP_011510480.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_011510480.1

    UniProtKB/Swiss-Prot
    Q96EH8
    Conserved Domains (4) summary
    smart00588
    Location:16 → 138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:20 → 85
    Neuralized; Neuralized
    pfam13920
    Location:200 → 247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19 → 171
    SPRY; SPRY domain

  3. XM_047446343.1 → XP_047302299.1  E3 ubiquitin-protein ligase NEURL3 isoform X2

    UniProtKB/TrEMBL
    A0A087WXE0
    Related
    ENSP00000480933.1, ENST00000435380.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    97004264..97014728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344577.1 → XP_054200552.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    UniProtKB/Swiss-Prot
    Q96EH8

  2. XM_054344576.1 → XP_054200551.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    UniProtKB/Swiss-Prot
    Q96EH8

  3. XM_054344578.1 → XP_054200553.1  E3 ubiquitin-protein ligase NEURL3 isoform X2

    UniProtKB/TrEMBL
    A0A087WXE0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080535.1: Suppressed sequence

    Description
    NM_001080535.1: This RefSeq was permanently suppressed because insufficient support for the specific combination of exons in the RefSeq record and the protein currently exists.

  2. NR_026875.1: Suppressed sequence

    Description
    NR_026875.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96EH8.2 GenPept UniProtKB/Swiss-Prot:Q96EH8

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