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NPIPA1 nuclear pore complex interacting protein family member A1 [ Homo sapiens (human) ]

Gene ID: 9284, updated on 3-Apr-2024

Summary

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Official Symbol
NPIPA1provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member A1provided by HGNC
Primary source
HGNC:HGNC:7909
See related
Ensembl:ENSG00000183426 MIM:606406; AllianceGenome:HGNC:7909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP; NPIPA; morpheus
Summary
Predicted to be involved in mRNA transport and protein transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 56.3), ovary (RPKM 53.3) and 25 other tissues See more
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Genomic context

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Location:
16p13.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14937443..14952056)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (14938510..14953106)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15031300..15045913)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PKD1P3-NPIPA1 readthrough Neighboring gene uncharacterized LOC100288162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15023765-15024578 Neighboring gene microRNA 6511a-1 Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 3 Neighboring gene microRNA 6770-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15041221-15041722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:15041723-15042222 Neighboring gene Sharpr-MPRA regulatory region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15068201-15068964 Neighboring gene pyridoxal dependent decarboxylase domain containing 1 Neighboring gene KIAA2013 pseudogene Neighboring gene microRNA 1972-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effects of lysophosphatidyl choline and phospholipase A on the lens. Cotlier E, et al. Invest Ophthalmol, 1975 Sep. PMID 1158635
  2. Positive selection of a gene family during the emergence of humans and African apes. Johnson ME, et al. Nature, 2001 Oct 4. PMID 11586358
  3. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. Hornan DM, et al. Invest Ophthalmol Vis Sci, 2007 Dec. PMID 18055785
  4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Loftus BJ, et al. Genomics, 1999 Sep 15. PMID 10493829
  5. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of nuclear pore complex interacting protein (NPIP) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
Knockdown of nuclear pore complex interacting protein (NPIP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough PKD1P3-NPIPA1

Readthrough gene: PKD1P3-NPIPA1, Included gene: PKD1P3

Homology

Clone Names

  • FLJ42525, FLJ44848

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member A1
Names
nuclear pore complex-interacting protein A type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006985.4 → NP_008916.2  nuclear pore complex-interacting protein family member A1

    See identical proteins and their annotated locations for NP_008916.2

    Status: VALIDATED

    Source sequence(s)
    AC138932, KF175225
    Consensus CDS
    CCDS10557.1
    UniProtKB/Swiss-Prot
    O15102, Q9UND3
    UniProtKB/TrEMBL
    A0A067ZUL9
    Related
    ENSP00000331843.6, ENST00000328085.10
    Conserved Domains (1) summary
    pfam06409
    Location:22 → 287
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    14937443..14952056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    776873..791391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329176.1 → XP_054185151.1  nuclear pore complex-interacting protein family member A1 isoform X3

  2. XM_054329173.1 → XP_054185148.1  nuclear pore complex-interacting protein family member A1 isoform X1

  3. XM_054329174.1 → XP_054185149.1  nuclear pore complex-interacting protein family member A1 isoform X2

  4. XM_045181393.2 → XP_045037328.1  nuclear pore complex-interacting protein family member A1 isoform X1

  5. XM_054329175.1 → XP_054185150.1  nuclear pore complex-interacting protein family member A1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    14938510..14953106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UND3.3 GenPept UniProtKB/Swiss-Prot:Q9UND3

Gene LinkOut

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