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MOB1B MOB kinase activator 1B [ Homo sapiens (human) ]

Gene ID: 92597, updated on 5-Mar-2024

Summary

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Official Symbol
MOB1Bprovided by HGNC
Official Full Name
MOB kinase activator 1Bprovided by HGNC
Primary source
HGNC:HGNC:29801
See related
Ensembl:ENSG00000173542 MIM:609282; AllianceGenome:HGNC:29801
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MATS2; MOB4A; MOBKL1A
Summary
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
4q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70901851..70988168)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (74244289..74330605)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71768086..71853885)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene uncharacterized LOC124900711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15473 Neighboring gene Sharpr-MPRA regulatory region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71869952-71870648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21605 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71883900-71884096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71894495-71894995 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71924658-71925260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71925261-71925861 Neighboring gene deoxycytidine kinase Neighboring gene solute carrier family 4 member 4 Neighboring gene uncharacterized LOC124900712

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human Mob1 proteins are required for cytokinesis by controlling microtubule stability. Florindo C, et al. J Cell Sci, 2012 Jul 1. PMID 22454515
  2. miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer. Pang H, et al. Cancer Sci, 2023 Apr. PMID 36445107, Free PMC Article
  3. Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling. Bae JS, et al. Cell Death Dis, 2018 Oct 22. PMID 30349003, Free PMC Article
  4. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Hergovich A, et al. Biochem Biophys Res Commun, 2006 Jun 23. PMID 16674920
  5. Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Bao Y, et al. Genes Cells, 2009 Dec. PMID 19919647

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer.
    Title: miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer.
  2. MOB1A/B has an essential function for intestinal epithelial homeostasis.
    Title: Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.
  3. Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis.
    Title: Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC33910

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MOB kinase activator 1B
Names
MOB1 Mps One Binder homolog B
MOB1, Mps One Binder kinase activator-like 1A
mob1 homolog 1A
mob1A
mps one binder kinase activator-like 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001244766.2 → NP_001231695.1  MOB kinase activator 1B isoform 1

    See identical proteins and their annotated locations for NP_001231695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC021989, AC093851, AK299481
    Consensus CDS
    CCDS58903.1
    UniProtKB/Swiss-Prot
    Q7L9L4
    Related
    ENSP00000379366.2, ENST00000396051.2
    Conserved Domains (1) summary
    pfam03637
    Location:38 → 209
    Mob1_phocein; Mob1/phocein family

  2. NM_001244767.2 → NP_001231696.1  MOB kinase activator 1B isoform 3

    See identical proteins and their annotated locations for NP_001231696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC108014, AK093545
    UniProtKB/TrEMBL
    B3KSH6, D6RCK3
    Related
    ENST00000509041.5
    Conserved Domains (1) summary
    pfam03637
    Location:33 → 139
    Mob1_phocein; Mob1/phocein family

  3. NM_173468.4 → NP_775739.1  MOB kinase activator 1B isoform 2

    See identical proteins and their annotated locations for NP_775739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC021989, AC093851, BC038112
    Consensus CDS
    CCDS34002.1
    UniProtKB/Swiss-Prot
    B2R8U6, B4DRY3, Q7L9L4, Q8IY23
    Related
    ENSP00000310189.3, ENST00000309395.7
    Conserved Domains (1) summary
    pfam03637
    Location:33 → 204
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    70901851..70988168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532412.3 → XP_011530714.1  MOB kinase activator 1B isoform X2

    Conserved Domains (1) summary
    pfam03637
    Location:57 → 228
    Mob1_phocein; Mob1/phocein family

  2. XM_005265709.3 → XP_005265766.1  MOB kinase activator 1B isoform X3

    See identical proteins and their annotated locations for XP_005265766.1

    UniProtKB/Swiss-Prot
    Q7L9L4
    Conserved Domains (1) summary
    pfam03637
    Location:38 → 209
    Mob1_phocein; Mob1/phocein family

  3. XM_017008837.2 → XP_016864326.1  MOB kinase activator 1B isoform X1

    Conserved Domains (1) summary
    pfam03637
    Location:64 → 235
    Mob1_phocein; Mob1/phocein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    74244289..74330605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351248.1 → XP_054207223.1  MOB kinase activator 1B isoform X2

  2. XM_054351249.1 → XP_054207224.1  MOB kinase activator 1B isoform X3

  3. XM_054351247.1 → XP_054207222.1  MOB kinase activator 1B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L9L4.3 GenPept UniProtKB/Swiss-Prot:Q7L9L4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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