AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AIMP1provided by HGNC
Official Full Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 1provided by HGNC
Primary source: HGNC:HGNC:10648
See related: Ensembl:ENSG00000164022 MIM:603605; AllianceGenome:HGNC:10648
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p43; HLD3; EMAP2; SCYE1; EMAPII
Summary: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Expression: Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (106315544..106349456)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (109626616..109660528)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (107236701..107270613)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) is a promising predictor for the severity of acute AQP4-IgG positive neuromyelitis optica spectrum disorder.
Title: Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) is a promising predictor for the severity of acute AQP4-IgG positive neuromyelitis optica spectrum disorder.
Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with beta-thalassemia major.
Title: Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major.
AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation.
Title: AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation.
EMAP II Expression Is Increased on Peripheral Blood Cells from Non-Hodgkin Lymphoma.
Title: EMAP II Expression Is Increased on Peripheral Blood Cells from Non-Hodgkin Lymphoma.
Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.
Title: Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein.
Clinical powers of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) for head-neck squamous cell carcinoma.
Title: Clinical powers of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) for head-neck squamous cell carcinoma.
the identification of FSCN1-binding partners enhances understanding of the mechanism of FSCN1-mediated malignant phenotypes, and these findings indicate that FSCN1 binds to AIMP1 and LTA4H might promote the progression of laryngeal squamous cell carcinoma .
Title: Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.
This novel homozygous mutation of the AIMP1 gene is characterized by preserved development of the periventricular and deep white matter structures as demonstrated by MRI and MR spectroscopy correlation.
Title: Novel Homozygous Mutation of the AIMP1 Gene: A Milder Neuroimaging Phenotype With Preservation of the Deep White Matter.
The results from our study suggest that serum AIMP1 can be used to estimate the cross-sectional severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) population based on the Birmingham vasculitis activity score.
Title: Serum Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein-1 Can Predict Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Pilot Monocentric Study.
The increase of EMAP-II serum level reflects an endothelial dysfunction in type 1 diabetes, alteration of carbohydrate and lipid metabolism could influence of this pathway.
Title: SERUM LEVELS OF ENDOTHELIAL MONOCYTE ACTIVATING PEPTIDE II IN TYPE 1 DIABETES.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hypomyelinating leukodystrophy 3 MedGen: C1850053 OMIM: 260600 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Tat	tat	SCYE1 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
matrix	gag	HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-132391 (e-PCR)
- UniSTS:170814

RH93669 (e-PCR)
- UniSTS:85346

SHGC-24759 (e-PCR)
- UniSTS:31095

SCYE1_2292 (e-PCR)
- UniSTS:280985

G35299 (e-PCR)
- UniSTS:30122

SHGC-59700 (e-PCR)
- UniSTS:23723

SHGC-67688 (e-PCR)
- UniSTS:53199

SHGC-57456 (e-PCR)
- UniSTS:46570

RH103971 (e-PCR)
- UniSTS:98296

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Names: ARS-interacting multifunctional protein 1; endothelial monocyte-activating polypeptide 2; endothelial-monocyte activating polypeptide II; multisynthase complex auxiliary component p43; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028166.1 RefSeqGene

Range

5941..38847

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142415.2 → NP_001135887.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

See identical proteins and their annotated locations for NP_001135887.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC093680, AK297950, BC014051, BM314663, BQ447202, DC358150

Consensus CDS

CCDS3674.1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9

UniProtKB/TrEMBL

B4DNK3

Conserved Domains (2) summary

PLN02610
Location:140 → 312

PLN02610; probable methionyl-tRNA synthetase

PRK00252
Location:15 → 78

alaS; alanyl-tRNA synthetase; Reviewed
NM_001142416.2 → NP_001135888.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC093680, AK303965, U10117

Consensus CDS

CCDS3674.1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9

UniProtKB/TrEMBL

B4DNK3

Related

ENSP00000500620.1, ENST00000672341.1

Conserved Domains (2) summary

PLN02610
Location:140 → 312

PLN02610; probable methionyl-tRNA synthetase

PRK00252
Location:15 → 78

alaS; alanyl-tRNA synthetase; Reviewed
NM_004757.4 → NP_004748.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

See identical proteins and their annotated locations for NP_004748.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC093680, AK095951, BC014051, BG941396, BM314663, BQ447202, DA211424

Consensus CDS

CCDS3674.1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9

UniProtKB/TrEMBL

B4DNK3

Related

ENSP00000350699.3, ENST00000358008.7

Conserved Domains (2) summary

PLN02610
Location:140 → 312

PLN02610; probable methionyl-tRNA synthetase

PRK00252
Location:15 → 78

alaS; alanyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

106315544..106349456

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047416410.1 → XP_047272366.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9

Related

ENSP00000500794.1, ENST00000673123.1
XM_017008835.3 → XP_016864324.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9

UniProtKB/TrEMBL

B4DNK3

Related

ENSP00000500025.1, ENST00000671960.1

Conserved Domains (2) summary

PLN02610
Location:140 → 312

PLN02610; probable methionyl-tRNA synthetase

PRK00252
Location:15 → 78

alaS; alanyl-tRNA synthetase; Reviewed

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

109626616..109660528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054351246.1 → XP_054207221.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

UniProtKB/Swiss-Prot

B3KTR2, B4E1S7, Q12904, Q6FG28, Q96CQ9