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LDHAL6B lactate dehydrogenase A like 6B [ Homo sapiens (human) ]

Gene ID: 92483, updated on 5-Mar-2024

Summary

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Official Symbol
LDHAL6Bprovided by HGNC
Official Full Name
lactate dehydrogenase A like 6Bprovided by HGNC
Primary source
HGNC:HGNC:21481
See related
Ensembl:ENSG00000171989 AllianceGenome:HGNC:21481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LDHL; LDH6B; LDHAL6
Summary
Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in pyruvate metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See LDHAL6B in Genome Data Viewer
Location:
15q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (59206843..59208588)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (57008917..57010662)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59499042..59500787)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:59423635-59424134 Neighboring gene cyclin B2 Neighboring gene Sharpr-MPRA regulatory region 4265 Neighboring gene myosin IE Neighboring gene OCT4 hESC enhancer GRCh37_chr15:59453332-59453833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9486 Neighboring gene microRNA 2116 Neighboring gene RNA, U4 small nuclear 80, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59521359-59521858 Neighboring gene Sharpr-MPRA regulatory region 2447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6487 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:59596416-59596592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9487 Neighboring gene NANOG hESC enhancer GRCh37_chr15:59620781-59621282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9488 Neighboring gene RNA, U6 small nuclear 212, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis. Wang H, et al. Int J Mol Med, 2005 Jun. PMID 15870898
  2. Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA). Chen X, et al. Mol Biol Rep, 2009 Apr. PMID 18351441
  3. Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1. Pioli PA, et al. J Biol Chem, 2002 Sep 20. PMID 12107167
  4. SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Chen LL, et al. Cell Rep, 2018 Nov 6. PMID 30404004, Free PMC Article
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Flachsbart F, et al. Mutat Res, 2010 Dec 10. PMID 20800603

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
part_of oxidoreductase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase A-like 6B
Names
lactate dehydrogenase A-like 6
testicular tissue protein Li 105
NP_149972.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033195.3 → NP_149972.1  L-lactate dehydrogenase A-like 6B

    See identical proteins and their annotated locations for NP_149972.1

    Status: VALIDATED

    Source sequence(s)
    AY642121, DB511998
    Consensus CDS
    CCDS10171.1
    UniProtKB/Swiss-Prot
    Q6DUY4, Q96LI2, Q9BYZ2
    UniProtKB/TrEMBL
    A0A140VJM9
    Related
    ENSP00000302393.4, ENST00000307144.6
    Conserved Domains (2) summary
    cd05293
    Location:68 → 376
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:74 → 374
    L-LDH-NAD; L-lactate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    59206843..59208588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    57008917..57010662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYZ2.3 GenPept UniProtKB/Swiss-Prot:Q9BYZ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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