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ZMYM6 zinc finger MYM-type containing 6 [ Homo sapiens (human) ]

Gene ID: 9204, updated on 5-Mar-2024

Summary

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Official Symbol
ZMYM6provided by HGNC
Official Full Name
zinc finger MYM-type containing 6provided by HGNC
Primary source
HGNC:HGNC:13050
See related
Ensembl:ENSG00000163867 MIM:613567; AllianceGenome:HGNC:13050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM; ZBED7; ZNF258; Buster2; ZNF198L4
Summary
Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 6.2), bone marrow (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (34986165..35031945, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (34848836..34894616, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35451766..35497546, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 199, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 634 Neighboring gene transmembrane protein 35B Neighboring gene ReSE screen-validated silencer GRCh37_chr1:35462847-35463058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35496848-35497374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:35497375-35497899 Neighboring gene uncharacterized LOC124903990 Neighboring gene ribosomal protein L12 pseudogene 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and mapping of members of the MYM family. Smedley D, et al. Genomics, 1999 Sep 1. PMID 10486218
  2. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. Lin X, et al. J Biol Chem, 2002 May 10. PMID 11884399
  3. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. Herrmann CH, et al. J Cell Sci, 2001 Apr. PMID 11282025
  4. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. Hayward A, et al. PLoS One, 2013. PMID 23533661, Free PMC Article
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger MYM-type protein 6
Names
transposon-derived Buster2 transposase-like protein
zinc finger protein 258
zinc finger, BED-type containing 7
zinc finger, MYM-type 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007167.4 → NP_009098.3  zinc finger MYM-type protein 6

    See identical proteins and their annotated locations for NP_009098.3

    Status: VALIDATED

    Source sequence(s)
    AL833263, BC068534, BC107880
    Consensus CDS
    CCDS387.2
    UniProtKB/Swiss-Prot
    B4DRJ6, O95789, Q32Q23, Q4G108, Q5SVZ9, Q5SW00, Q69YL4, Q96IY0, Q9NWF1, Q9P2J4
    Related
    ENSP00000349708.4, ENST00000357182.9
    Conserved Domains (2) summary
    smart00746
    Location:193 → 228
    TRASH; metallochaperone-like domain
    pfam06467
    Location:131 → 174
    zf-FCS; MYM-type Zinc finger with FCS sequence motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    34986165..35031945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    34848836..34894616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024933.1: Suppressed sequence

    Description
    NM_001024933.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_145310.2: Suppressed sequence

    Description
    NM_145310.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  3. NM_153248.2: Suppressed sequence

    Description
    NM_153248.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95789.2 GenPept UniProtKB/Swiss-Prot:O95789

Gene LinkOut

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