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BOC BOC cell adhesion associated, oncogene regulated [ Homo sapiens (human) ]

Gene ID: 91653, updated on 5-Mar-2024

Summary

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Official Symbol
BOCprovided by HGNC
Official Full Name
BOC cell adhesion associated, oncogene regulatedprovided by HGNC
Primary source
HGNC:HGNC:17173
See related
Ensembl:ENSG00000144857 MIM:608708; AllianceGenome:HGNC:17173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Boi; CDON2
Summary
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Broad expression in skin (RPKM 11.2), prostate (RPKM 10.0) and 23 other tissues See more
Orthologs
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Genomic context

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See BOC in Genome Data Viewer
Location:
3q13.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113210926..113287459)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115932521..116008527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112930404..113006306)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NEPRO antisense RNA 1 Neighboring gene uncharacterized LOC124906268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112842917-112843418 Neighboring gene long intergenic non-protein coding RNA 2044 Neighboring gene uncharacterized LOC124909486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112930765-112931416 Neighboring gene uncharacterized LOC124909409 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112983897-112984515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112991758-112992620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20249 Neighboring gene SPICE1-CFAP44 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:113031132-113031687 Neighboring gene cilia and flagella associated protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113085321-113085822 Neighboring gene Sharpr-MPRA regulatory region 3247 Neighboring gene RABGGTB pseudogene 1 Neighboring gene PHF5A pseudogene 2 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20251 Neighboring gene microRNA 8076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BOC is a modifier gene in holoprosencephaly. Hong M, et al. Hum Mutat, 2017 Nov. PMID 28677295, Free PMC Article
  2. Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis. Dai Z, et al. Spine (Phila Pa 1976), 2021 Nov 15. PMID 33958541
  3. Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics. Ahmed S, et al. Heart Vessels, 2020 Nov. PMID 32651845, Free PMC Article
  4. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. Onodera S, et al. PLoS One, 2017. PMID 28915250, Free PMC Article
  5. Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. Wegorzewska M, et al. Mol Carcinog, 2003 May. PMID 12720294

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.
    Title: Female-Specific Susceptibility Locus in BOC and SEC16B are Associated with Adolescent Idiopathic Scoliosis.
  2. Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics.
    Title: Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics.
  3. we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays.
    Title: BOC is a modifier gene in holoprosencephaly.
  4. BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
    Title: A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation.
  5. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype
    Title: Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype.
  6. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner
    Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
  7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
  8. Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm.
    Title: Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc.
  9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage
    Title: Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD.
  10. Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity.
    Title: The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
brother of CDO
Names
Boc homolog
brother of CDON
cell adhesion associated, oncogene regulated 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301861.2 → NP_001288790.1  brother of CDO isoform 1 precursor

    See identical proteins and their annotated locations for NP_001288790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA716090, AC026329, AK074556, AY027658, AY358328, BC075829, DA247804, DB349011
    Consensus CDS
    CCDS77788.1
    UniProtKB/Swiss-Prot
    Q9BWV1
    Related
    ENSP00000273395.4, ENST00000273395.8
    Conserved Domains (6) summary
    cd00063
    Location:607 → 698
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 560
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  2. NM_001301867.2 → NP_001288796.1  brother of CDO isoform 3 precursor

    See identical proteins and their annotated locations for NP_001288796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC026329, AK056359, BC034614, BC075829, DA721979
    Consensus CDS
    CCDS77789.1
    UniProtKB/TrEMBL
    Q96DN7
    Related
    ENSP00000420154.1, ENST00000485230.5
    Conserved Domains (2) summary
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    cd00096
    Location:53 → 59
    Ig; Ig strand B [structural motif]

  3. NM_001378073.1 → NP_001365002.1  brother of CDO isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS77788.1
    Conserved Domains (6) summary
    cd00063
    Location:607 → 698
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 560
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  4. NM_001378074.1 → NP_001365003.1  brother of CDO isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS77788.1
    Related
    ENSP00000507783.1, ENST00000682979.1
    Conserved Domains (6) summary
    cd00063
    Location:607 → 698
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 560
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  5. NM_001378075.1 → NP_001365004.1  brother of CDO isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS2971.1
    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  6. NM_001387919.1 → NP_001374848.1  brother of CDO isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS77788.1
    Conserved Domains (6) summary
    cd00063
    Location:607 → 698
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 560
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  7. NM_001387920.1 → NP_001374849.1  brother of CDO isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS2971.1
    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  8. NM_001387921.1 → NP_001374850.1  brother of CDO isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS2971.1
    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  9. NM_001387922.1 → NP_001374851.1  brother of CDO isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS77789.1
    UniProtKB/TrEMBL
    Q96DN7
    Conserved Domains (2) summary
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    cd00096
    Location:53 → 59
    Ig; Ig strand B [structural motif]

  10. NM_001387923.1 → NP_001374852.1  brother of CDO isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Consensus CDS
    CCDS77789.1
    UniProtKB/TrEMBL
    Q96DN7
    Conserved Domains (2) summary
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    cd00096
    Location:53 → 59
    Ig; Ig strand B [structural motif]

  11. NM_001387924.1 → NP_001374853.1  brother of CDO isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (6) summary
    cd00063
    Location:516 → 607
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:395 → 469
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:321 → 382
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  12. NM_001387925.1 → NP_001374854.1  brother of CDO isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  13. NM_001387926.1 → NP_001374855.1  brother of CDO isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (6) summary
    cd00063
    Location:607 → 698
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 560
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  14. NM_001387927.1 → NP_001374856.1  brother of CDO isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  15. NM_001387928.1 → NP_001374857.1  brother of CDO isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  16. NM_001387929.1 → NP_001374858.1  brother of CDO isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (4) summary
    pfam13927
    Location:322 → 395
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  17. NM_001387930.1 → NP_001374859.1  brother of CDO isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (4) summary
    pfam13927
    Location:322 → 395
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  18. NM_001387932.1 → NP_001374861.1  brother of CDO isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC026329
    Conserved Domains (3) summary
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    cd00096
    Location:53 → 59
    Ig; Ig strand B [structural motif]
    cl11960
    Location:129 → 204
    Ig; Immunoglobulin domain

  19. NM_033254.4 → NP_150279.1  brother of CDO isoform 2 precursor

    See identical proteins and their annotated locations for NP_150279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AA716090, AK074556, AY027658, AY358328, BC075829, DA721979, DB349011
    Consensus CDS
    CCDS2971.1
    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
    Related
    ENSP00000418663.1, ENST00000495514.5
    Conserved Domains (6) summary
    cd00063
    Location:606 → 697
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:486 → 559
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:409 → 473
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

RNA

  1. NR_170866.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026329

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    113210926..113287459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449188.1 → XP_047305144.1  brother of CDO isoform X11

  2. XM_047449184.1 → XP_047305140.1  brother of CDO isoform X9

  3. XM_047449186.1 → XP_047305142.1  brother of CDO isoform X11

  4. XM_047449187.1 → XP_047305143.1  brother of CDO isoform X11

  5. XM_047449173.1 → XP_047305129.1  brother of CDO isoform X1

  6. XM_017007446.2 → XP_016862935.1  brother of CDO isoform X5

    Conserved Domains (6) summary
    cd00063
    Location:610 → 701
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:489 → 563
    fn3; Fibronectin type III domain
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    pfam16625
    Location:414 → 476
    ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO
    cd00096
    Location:248 → 252
    Ig; Ig strand B [structural motif]
    cl11960
    Location:239 → 306
    Ig; Immunoglobulin domain

  7. XM_047449177.1 → XP_047305133.1  brother of CDO isoform X2

  8. XM_017007450.3 → XP_016862939.1  brother of CDO isoform X6

  9. XM_047449178.1 → XP_047305134.1  brother of CDO isoform X3

  10. XM_047449181.1 → XP_047305137.1  brother of CDO isoform X7

  11. XM_047449180.1 → XP_047305136.1  brother of CDO isoform X4

  12. XM_047449182.1 → XP_047305138.1  brother of CDO isoform X8

    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1
    Related
    ENSP00000347546.3, ENST00000355385.7

  13. XM_047449185.1 → XP_047305141.1  brother of CDO isoform X10

  14. XM_047449189.1 → XP_047305145.1  brother of CDO isoform X12

  15. XM_047449190.1 → XP_047305146.1  brother of CDO isoform X13

  16. XM_047449175.1 → XP_047305131.1  brother of CDO isoform X1

  17. XM_047449183.1 → XP_047305139.1  brother of CDO isoform X8

    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

  18. XM_047449191.1 → XP_047305147.1  brother of CDO isoform X14

  19. XM_047449179.1 → XP_047305135.1  brother of CDO isoform X3

  20. XM_047449192.1 → XP_047305148.1  brother of CDO isoform X15

  21. XM_017007455.2 → XP_016862944.1  brother of CDO isoform X16

    UniProtKB/TrEMBL
    Q96DN7
    Related
    ENSP00000417337.1, ENST00000484034.1
    Conserved Domains (2) summary
    pfam13927
    Location:36 → 109
    Ig_3; Immunoglobulin domain
    cd00096
    Location:53 → 59
    Ig; Ig strand B [structural motif]

  22. XM_047449176.1 → XP_047305132.1  brother of CDO isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    115932521..116008527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348348.1 → XP_054204323.1  brother of CDO isoform X9

  2. XM_054348350.1 → XP_054204325.1  brother of CDO isoform X11

  3. XM_054348351.1 → XP_054204326.1  brother of CDO isoform X11

  4. XM_054348336.1 → XP_054204311.1  brother of CDO isoform X1

  5. XM_054348343.1 → XP_054204318.1  brother of CDO isoform X5

  6. XM_054348339.1 → XP_054204314.1  brother of CDO isoform X2

  7. XM_054348344.1 → XP_054204319.1  brother of CDO isoform X6

  8. XM_054348340.1 → XP_054204315.1  brother of CDO isoform X3

  9. XM_054348345.1 → XP_054204320.1  brother of CDO isoform X7

  10. XM_054348342.1 → XP_054204317.1  brother of CDO isoform X4

  11. XM_054348346.1 → XP_054204321.1  brother of CDO isoform X8

    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

  12. XM_054348349.1 → XP_054204324.1  brother of CDO isoform X10

  13. XM_054348352.1 → XP_054204327.1  brother of CDO isoform X12

  14. XM_054348353.1 → XP_054204328.1  brother of CDO isoform X13

  15. XM_054348337.1 → XP_054204312.1  brother of CDO isoform X1

  16. XM_054348347.1 → XP_054204322.1  brother of CDO isoform X8

    UniProtKB/Swiss-Prot
    A6NJ30, B2RMS8, D3DN70, Q6UXJ5, Q8N2P7, Q8NF26, Q9BWV1

  17. XM_054348354.1 → XP_054204329.1  brother of CDO isoform X14

  18. XM_054348341.1 → XP_054204316.1  brother of CDO isoform X3

  19. XM_054348355.1 → XP_054204330.1  brother of CDO isoform X15

  20. XM_054348356.1 → XP_054204331.1  brother of CDO isoform X16

    UniProtKB/TrEMBL
    Q96DN7

  21. XM_054348338.1 → XP_054204313.1  brother of CDO isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWV1.1 GenPept UniProtKB/Swiss-Prot:Q9BWV1

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