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RASL10B RAS like family 10 member B [ Homo sapiens (human) ]

Gene ID: 91608, updated on 5-Mar-2024

Summary

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Official Symbol
RASL10Bprovided by HGNC
Official Full Name
RAS like family 10 member Bprovided by HGNC
Primary source
HGNC:HGNC:30295
See related
Ensembl:ENSG00000270885 MIM:612128; AllianceGenome:HGNC:30295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP17; VTS58635
Summary
Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 7.3), heart (RPKM 2.8) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35731639..35743521)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36679576..36691458)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34058658..34070540)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 160 pseudogene Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:33957282-33958481 Neighboring gene MPRA-validated peak2820 silencer Neighboring gene Sharpr-MPRA regulatory region 1039 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34059551-34060074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene growth arrest specific 2 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8441 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. Zou H, et al. Biotechnol Lett, 2006 Dec. PMID 17028781
  2. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. Rybkin II, et al. J Cell Biol, 2007 Nov 5. PMID 17984325, Free PMC Article
  3. Systematic identification of molecular links between core and candidate genes in breast cancer. Arroyo R, et al. J Mol Biol, 2015 Mar 27. PMID 25640309
  4. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RRP17 is a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues
    Title: Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein.
  2. RasL10B is a new member of Ras superfamily with tumor suppressor potential
    Title: Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC47540

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of peptide hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-like protein family member 10B
Names
Ras-related protein 17
alternative protein RASL10B
ras-like protein VTS58635
NP_201572.1
XP_016880789.1
XP_047292999.1
XP_054173738.1
XP_054173739.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033315.4 → NP_201572.1  ras-like protein family member 10B

    See identical proteins and their annotated locations for NP_201572.1

    Status: VALIDATED

    Source sequence(s)
    AC006237, AK122652, BC041133, DA250459
    Consensus CDS
    CCDS11297.1
    UniProtKB/Swiss-Prot
    B3KV31, Q96S79
    Related
    ENSP00000474230.1, ENST00000603017.2
    Conserved Domains (1) summary
    cd04142
    Location:5 → 203
    RRP22; Ras-related protein on chromosome 22 (RRP22) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35731639..35743521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437043.1 → XP_047292999.1  ras-like protein family member 10B isoform X1

  2. XM_017025300.2 → XP_016880789.1  ras-like protein family member 10B isoform X2

RNA

  1. XR_934595.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36679576..36691458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317763.1 → XP_054173738.1  ras-like protein family member 10B isoform X1

  2. XM_054317764.1 → XP_054173739.1  ras-like protein family member 10B isoform X2

RNA

  1. XR_008484962.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96S79.1 GenPept UniProtKB/Swiss-Prot:Q96S79

Gene LinkOut

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