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NUP210L nucleoporin 210 like [ Homo sapiens (human) ]

Gene ID: 91181, updated on 7-Apr-2024

Summary

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Official Symbol
NUP210Lprovided by HGNC
Official Full Name
nucleoporin 210 likeprovided by HGNC
Primary source
HGNC:HGNC:29915
See related
Ensembl:ENSG00000143552 AllianceGenome:HGNC:29915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to act upstream of or within Sertoli cell development and spermatid development. Predicted to be integral component of membrane. Predicted to be part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 16.4) See more
Orthologs
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Genomic context

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Location:
1q21.3
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153992690..154155116, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153129953..153292344, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153965166..154127592, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:153958417-153958918 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:153962963-153964162 Neighboring gene uncharacterized LOC124904673 Neighboring gene RAB13, member RAS oncogene family Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153979675-153979936 Neighboring gene ribosomal protein L34 pseudogene 5 Neighboring gene ribosomal protein S27 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:154010667-154010888 Neighboring gene RNA, U6 small nuclear 179, pseudogene Neighboring gene ribosomal protein S7 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154070062-154070562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154070563-154071063 Neighboring gene microRNA 5698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154126882-154127382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154127383-154127883 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:154128490-154128667 Neighboring gene RNA, 7SL, cytoplasmic 431, pseudogene Neighboring gene tropomyosin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154152669-154153665 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:154154639-154155265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1773 Neighboring gene microRNA 190b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Li X, et al. Mol Cell Proteomics, 2016 Sep. PMID 27432908, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear pore membrane glycoprotein 210-like
Names
nuclear pore membrane glycoprotein 210-like (LOC91181)
nucleoporin 210kDa like
nucleoporin Nup210-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159484.1 → NP_001152956.1  nuclear pore membrane glycoprotein 210-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two coding exons in the 3' region, compared to variant 1. The resulting isoform (2) lacks an internal segment but has identical N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK128000, AL133633, AL513546, AL833964, BX648132
    Consensus CDS
    CCDS53370.1
    UniProtKB/Swiss-Prot
    Q5VU65
    Related
    ENSP00000271854.3, ENST00000271854.3
    Conserved Domains (1) summary
    pfam02368
    Location:1083 → 1157
    Big_2; Bacterial Ig-like domain (group 2)

  2. NM_207308.3 → NP_997191.2  nuclear pore membrane glycoprotein 210-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_997191.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL358472, AL513546, AL590431
    Consensus CDS
    CCDS41399.1
    UniProtKB/Swiss-Prot
    E7EP56, Q5T4L7, Q5VU65, Q6ZRN1, Q6ZRT4, Q6ZU81, Q8NDI6, Q9UF31
    Related
    ENSP00000357547.3, ENST00000368559.8
    Conserved Domains (2) summary
    pfam02368
    Location:1083 → 1157
    Big_2; Bacterial Ig-like domain (group 2)
    cl00732
    Location:274 → 383
    Arch_flagellin; Archaebacterial flagellin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153992690..154155116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510122.2 → XP_011508424.1  nuclear pore membrane glycoprotein 210-like isoform X2

    Conserved Domains (2) summary
    pfam02368
    Location:1039 → 1113
    Big_2; Bacterial Ig-like domain (group 2)
    cl00732
    Location:230 → 339
    Arch_flagellin; Archaebacterial flagellin

  2. XM_011510123.2 → XP_011508425.1  nuclear pore membrane glycoprotein 210-like isoform X3

    Conserved Domains (2) summary
    pfam02368
    Location:1083 → 1157
    Big_2; Bacterial Ig-like domain (group 2)
    cl00732
    Location:274 → 383
    Arch_flagellin; Archaebacterial flagellin

  3. XM_017002788.3 → XP_016858277.1  nuclear pore membrane glycoprotein 210-like isoform X1

  4. XM_047433904.1 → XP_047289860.1  nuclear pore membrane glycoprotein 210-like isoform X6

  5. XM_011510124.2 → XP_011508426.1  nuclear pore membrane glycoprotein 210-like isoform X4

    Conserved Domains (2) summary
    pfam02368
    Location:1083 → 1157
    Big_2; Bacterial Ig-like domain (group 2)
    cl00732
    Location:274 → 383
    Arch_flagellin; Archaebacterial flagellin

  6. XM_017002789.3 → XP_016858278.1  nuclear pore membrane glycoprotein 210-like isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    153129953..153292344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339547.1 → XP_054195522.1  nuclear pore membrane glycoprotein 210-like isoform X2

  2. XM_054339548.1 → XP_054195523.1  nuclear pore membrane glycoprotein 210-like isoform X3

  3. XM_054339546.1 → XP_054195521.1  nuclear pore membrane glycoprotein 210-like isoform X1

  4. XM_054339551.1 → XP_054195526.1  nuclear pore membrane glycoprotein 210-like isoform X6

  5. XM_054339549.1 → XP_054195524.1  nuclear pore membrane glycoprotein 210-like isoform X4

  6. XM_054339550.1 → XP_054195525.1  nuclear pore membrane glycoprotein 210-like isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VU65.1 GenPept UniProtKB/Swiss-Prot:Q5VU65

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