MTA1 metastasis associated 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MTA1provided by HGNC
Official Full Name: metastasis associated 1provided by HGNC
Primary source: HGNC:HGNC:7410
See related: Ensembl:ENSG00000182979 MIM:603526; AllianceGenome:HGNC:7410
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in testis (RPKM 14.9), spleen (RPKM 9.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.33

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (105419827..105470729)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (99667356..99717871)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (105886164..105937066)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTA1 as negative prognostic marker in vulvar carcinoma.
Title: MTA1 as negative prognostic marker in vulvar carcinoma.
RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs.
Title: RNAi Screen Identifies MTA1 as an Epigenetic Modifier of Differentiation Commitment in Human HSPCs.
MTA1: A Vital Modulator in Prostate Cancer.
Title: MTA1: A Vital Modulator in Prostate Cancer.
Correlation between metastasis-associated gene 1 expression and tumor-associated macrophages in non-small cell lung cancer.
Title: Correlation between metastasis-associated gene 1 expression and tumor-associated macrophages in non-small cell lung cancer.
Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer.
Title: Metastasis-associated protein 1: A potential driver and regulator of the hallmarks of cancer.
[The role and mechanism of tumor metastasis-associated gene 1 in radiosensitivity of HeLa cells].
Title: [The role and mechanism of tumor metastasis-associated gene 1 in radiosensitivity of HeLa cells].
Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy.
Title: Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy.
miR-30 inhibits the progression of osteosarcoma by targeting MTA1.
Title: miR-30 inhibits the progression of osteosarcoma by targeting MTA1.
RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma.
Title: RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma.
Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity.
Title: Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity.

Submit: New GeneRIF Correction See all GeneRIFs (205)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	BCL11B and metastasis associated 1 protein (MTA1) inhibits HIV-1 Tat-mediated LTR transactivation by association with the integrated HIV-LTR	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44555 (e-PCR)
- UniSTS:36647

RH15744 (e-PCR)
- UniSTS:36648

WI-16962 (e-PCR)
- UniSTS:41282

A008K08 (e-PCR)
- UniSTS:18002

SGC34279 (e-PCR)
- UniSTS:52830

RH44655 (e-PCR)
- UniSTS:52831

RH78599 (e-PCR)
- UniSTS:55706

RH45087 (e-PCR)
- UniSTS:60828

G36209 (e-PCR)
- UniSTS:38581

G35503 (e-PCR)
- UniSTS:39377

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell fate specification	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stem cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuRD complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metastasis-associated protein MTA1

Names: metastasis associated gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029515.2 RefSeqGene

Range

5002..55904

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203258.2 → NP_001190187.1 metastasis-associated protein MTA1 isoform MTA1s

See identical proteins and their annotated locations for NP_001190187.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (MTA1s) has a shorter and distinct C-terminus compared to isoform MTA1.

Source sequence(s)

AL928654

Consensus CDS

CCDS55954.1

UniProtKB/Swiss-Prot

Q13330

UniProtKB/TrEMBL

Q9BRL8

Related

ENSP00000393438.1, ENST00000438610.5

Conserved Domains (4) summary

smart00717
Location:286 → 333

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain
NM_001411061.1 → NP_001397990.1 metastasis-associated protein MTA1 isoform 3

Status: REVIEWED

Source sequence(s)

AL928654

Consensus CDS

CCDS91956.1

UniProtKB/TrEMBL

E7ESY4

Related

ENSP00000385702.1, ENST00000406191.5
NM_001411062.1 → NP_001397991.1 metastasis-associated protein MTA1 isoform 4

Status: REVIEWED

Source sequence(s)

AL928654

Consensus CDS

CCDS91957.1

Related

ENSP00000384180.1, ENST00000405646.5
NM_004689.4 → NP_004680.2 metastasis-associated protein MTA1 isoform MTA1

See identical proteins and their annotated locations for NP_004680.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (MTA1).

Source sequence(s)

AL928654

Consensus CDS

CCDS32169.1

UniProtKB/Swiss-Prot

A5PLK4, Q13330, Q86SW2, Q8NFI8, Q96GI8

Related

ENSP00000333633.7, ENST00000331320.12

Conserved Domains (5) summary

cd11661
Location:287 → 332

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:388 → 441

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd04709
Location:3 → 188

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:167 → 219

ELM2; ELM2 domain

pfam17226
Location:464 → 541

MTA_R1; MTA R1 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

105419827..105470729

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047431904.1 → XP_047287860.1 metastasis-associated protein MTA1 isoform X13
XM_047431906.1 → XP_047287862.1 metastasis-associated protein MTA1 isoform X14
XM_047431908.1 → XP_047287864.1 metastasis-associated protein MTA1 isoform X15
XM_011537305.1 → XP_011535607.1 metastasis-associated protein MTA1 isoform X7

Conserved Domains (6) summary

smart00717
Location:342 → 389

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:343 → 388

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:444 → 497

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:448 → 504

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 244

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:223 → 275

ELM2; ELM2 domain
XM_011537306.1 → XP_011535608.1 metastasis-associated protein MTA1 isoform X8

Conserved Domains (6) summary

smart00717
Location:342 → 389

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:343 → 388

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:444 → 497

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:448 → 504

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 244

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:223 → 275

ELM2; ELM2 domain
XM_011537307.1 → XP_011535609.1 metastasis-associated protein MTA1 isoform X9

Conserved Domains (6) summary

smart00717
Location:342 → 389

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:343 → 388

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:444 → 497

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:448 → 504

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 244

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:223 → 275

ELM2; ELM2 domain
XM_011537308.3 → XP_011535610.1 metastasis-associated protein MTA1 isoform X10

Conserved Domains (6) summary

smart00717
Location:325 → 372

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:326 → 371

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:427 → 480

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:431 → 487

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 227

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:206 → 258

ELM2; ELM2 domain
XM_011537309.1 → XP_011535611.1 metastasis-associated protein MTA1 isoform X11

Conserved Domains (6) summary

smart00717
Location:325 → 372

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:326 → 371

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:427 → 480

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:431 → 487

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 227

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:206 → 258

ELM2; ELM2 domain
XM_011537310.1 → XP_011535612.1 metastasis-associated protein MTA1 isoform X12

Conserved Domains (6) summary

smart00717
Location:325 → 372

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11661
Location:326 → 371

SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins

smart00401
Location:427 → 480

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:431 → 487

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

cd04709
Location:64 → 227

BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...

pfam01448
Location:206 → 258

ELM2; ELM2 domain
XM_047431910.1 → XP_047287866.1 metastasis-associated protein MTA1 isoform X17
XM_047431901.1 → XP_047287857.1 metastasis-associated protein MTA1 isoform X4
XM_047431903.1 → XP_047287859.1 metastasis-associated protein MTA1 isoform X6
XM_047431898.1 → XP_047287854.1 metastasis-associated protein MTA1 isoform X1
XM_047431900.1 → XP_047287856.1 metastasis-associated protein MTA1 isoform X3
XM_047431902.1 → XP_047287858.1 metastasis-associated protein MTA1 isoform X5
XM_047431899.1 → XP_047287855.1 metastasis-associated protein MTA1 isoform X2
XM_047431909.1 → XP_047287865.1 metastasis-associated protein MTA1 isoform X16