TRIM41 tripartite motif containing 41 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM41provided by HGNC
Official Full Name: tripartite motif containing 41provided by HGNC
Primary source: HGNC:HGNC:19013
See related: Ensembl:ENSG00000146063 MIM:610530; AllianceGenome:HGNC:19013
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RINCK
Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (181223281..181235808)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (181783233..181795759)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (180650281..180662808)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation.
Title: Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation.
TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.
Title: TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.
ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation.
Title: ANXA10 promotes melanoma metastasis by suppressing E3 ligase TRIM41-directed PKD1 degradation.
TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection.
Title: TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection.
deregulation of the TRIM17/TRIM41/ZSCAN21 pathway may be involved in the pathogenesis of Parkinson's disease.
Title: The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.
Taking these observations together, TRIM41 is a constitutively expressed intrinsic influenza A virus restriction factor that targets viral NP for ubiquitination and protein degradation.
Title: TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection.
RINCK is an E3 ligase that specifically recognizes the C1 domain of PKC isoforms
Title: Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.
observed in the cytoplasm and the nucleus; nuclear transport is mediated by an N-terminal segment common to both alpha and beta isoforms, but independent of a classical nuclear localization signal sequence.
Title: Intracellular localization and domain organization of human TRIM41 proteins.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12310 (e-PCR)
- UniSTS:2838

L28233 (e-PCR)
- UniSTS:53823

NoName (e-PCR)
- UniSTS:484787

SGC31965 (e-PCR)
- UniSTS:950

D5S1648E (e-PCR)
- UniSTS:24796

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleolus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM41

Names: RING finger-interacting protein with C kinase; RING-finger protein that interacts with C kinase; RING-type E3 ubiquitin transferase TRIM41

NP_291027.3

EC 2.3.2.27

NP_963921.1

EC 2.3.2.27

XP_006714992.1

EC 2.3.2.27

XP_006714993.1

EC 2.3.2.27

XP_006714994.1

EC 2.3.2.27

XP_006714995.1

EC 2.3.2.27

XP_047273824.1

EC 2.3.2.27

XP_054209740.1

EC 2.3.2.27

XP_054209741.1

EC 2.3.2.27

XP_054209742.1

EC 2.3.2.27

XP_054209743.1

EC 2.3.2.27

XP_054209744.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030346.1 RefSeqGene

Range

5019..17546

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_033549.5 → NP_291027.3 E3 ubiquitin-protein ligase TRIM41 isoform 1

See identical proteins and their annotated locations for NP_291027.3

Status: REVIEWED

Description

Transcript Variant: This variant (1, also referred to as alpha) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

BC018765, BC090953, DA341383

Consensus CDS

CCDS4466.1

UniProtKB/Swiss-Prot

B3KNJ6, D3DWR9, Q5BKT0, Q7L484, Q8WV44, Q96Q10, Q9BSL8

Related

ENSP00000320869.5, ENST00000315073.10

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd13741
Location:432 → 630

SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_201627.3 → NP_963921.1 E3 ubiquitin-protein ligase TRIM41 isoform 2

See identical proteins and their annotated locations for NP_963921.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also referred to as beta) includes several alternate exons and an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a distinct C-terminus, compared to isoform.

Source sequence(s)

AK027601, BC018765, BC090953, DA341383

Consensus CDS

CCDS4465.1

UniProtKB/Swiss-Prot

Q8WV44

Related

ENSP00000336749.6, ENST00000351937.9

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02614
Location:432 → 489

SPRY; SPRY domain

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

NR_045218.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes several alternate exons and an alternate splice pattern, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK027601, BC004956, BC018765, DA341383

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

181223281..181235808

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006714929.3 → XP_006714992.1 E3 ubiquitin-protein ligase TRIM41 isoform X1

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02614
Location:432 → 498

SPRY; SPRY domain

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_006714932.4 → XP_006714995.1 E3 ubiquitin-protein ligase TRIM41 isoform X4

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02614
Location:432 → 498

SPRY; SPRY domain

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_006714930.3 → XP_006714993.1 E3 ubiquitin-protein ligase TRIM41 isoform X2

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02614
Location:432 → 489

SPRY; SPRY domain

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
XM_047417868.1 → XP_047273824.1 E3 ubiquitin-protein ligase TRIM41 isoform X5
XM_006714931.4 → XP_006714994.1 E3 ubiquitin-protein ligase TRIM41 isoform X3

Conserved Domains (5) summary

cd00021
Location:226 → 263

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam01442
Location:263 → 374

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl00459
Location:286 → 381

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl02614
Location:432 → 491

SPRY; SPRY domain

cl17238
Location:20 → 48

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...